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Lung Ultrasound in Emergency and Critically Ill Patients Number of Supervised Exams to Reach Basic Competence

期刊: ANESTHESIOLOGY, 2020; 132 (4)

Background: Lung ultrasound is increasingly used in critically ill patients as an alternative to bedside chest radiography, but the best training meth......

Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion

期刊: ANESTHESIOLOGY, 2020; 132 (4)

Background: During myocardial ischemia, hypoxia-inducible factors are stabilized and provide protection from ischemia and reperfusion injury. Recent s......

One-year Results of a Factorial Randomized Trial of Aspirin versus Placebo and Clonidine versus Placebo in Patients Having Noncardiac Surgery

期刊: ANESTHESIOLOGY, 2020; 132 (4)

Background: The authors previously reported that perioperative aspirin and/or clonidine does not prevent a composite of death or myocardial infarction......

Synaptic Dynamics of the Feed-forward Inhibitory Circuitry Gating Mechanical Allodynia in Mice

期刊: ANESTHESIOLOGY, 2020; 132 (5)

Background: The authors' previous studies have found that spinal protein kinase C gamma expressing neurons are involved in the feed-forward inhibitory......

A Central Amygdala-Ventrolateral Periaqueductal Gray Matter Pathway for Pain in a Mouse Model of Depression-like Behavior

期刊: ANESTHESIOLOGY, 2020; 132 (5)

Background: The mechanisms underlying depression-associated pain remain poorly understood. Using a mouse model of depression, the authors hypothesized......

Dantrolene Ameliorates Impaired Neurogenesis and Synaptogenesis in Induced Pluripotent Stem Cell Lines Derived from Patients with Alzheimer's Disease

期刊: ANESTHESIOLOGY, 2020; 132 (5)

Background: Overactivation of ryanodine receptors and the resulting impaired calcium homeostasis contribute to Alzheimer's disease-related pathophysio......

Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice

期刊: ANESTHESIOLOGY, 2020; 132 (6)

Background: Patients undergoing cancer treatment often experience chemotherapy-induced neuropathic pain at their extremities, for which there is no U.......

Inhibition of Sphingosine Kinase 1 Attenuates Sepsis-induced Microvascular Leakage via Inhibiting Macrophage NLRP3 Inflammasome Activation in Mice

期刊: ANESTHESIOLOGY, 2020; 132 (6)

Background: Sepsis is the overwhelming inflammatory response to infection, in which nucleotide-binding oligomerization domain-like receptor containing......

Neurally Adjusted Ventilatory Assist versus Pressure Support Ventilation in Difficult Weaning: A Randomized Trial

期刊: ANESTHESIOLOGY, 2020; 132 (6)

Background: Difficult weaning frequently develops in ventilated patients and is associated with poor outcome. In neurally adjusted ventilatory assist,......

Sevoflurane Enhances Proliferation, Metastatic Potential of Cervical Cancer Cells via the Histone Deacetylase 6 Modulation In Vitro

期刊: ANESTHESIOLOGY, 2020; 132 (6)

Background: Sevoflurane is commonly used for cervical cancer surgery, but its effect on cervical cancer cell biology remains unclear. This mechanistic......

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