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Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2021; 35 (8)

Aims: This study aims to explore the efficacy of punicalagin (PG) on diabetic cardiomyopathy (DCM), with a specific focus on the mechanisms underlying......

New Therapeutic Approaches Using Hydrogen Sulfide Donors in Inflammation and Immune Response

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2021; 35 (5)

Significance: Inflammation and immune response are associated with many pathological disorders, including rheumatoid arthritis, lupus, heart failure, ......

Different Roles of Stem/Progenitor Cells in Vascular Remodeling

期刊: ANTIOXIDANTS & REDOX SIGNALING, ; ()

Significance: Since the discovery of vascular stem cells, there has been considerable advancement in comprehending the nature and functions of these c......

Targeting Hypoxia-Inducible Factor-1-Mediated Metastasis for Cancer Therapy

期刊: ANTIOXIDANTS & REDOX SIGNALING, ; ()

Significance: Hypoxia is emerging as a crucial regulator of the tumor microenvironment; it governs the metastatic potential of multiple primary cancer......

Silencing of Central (Pro)renin Receptor Ameliorates Salt-Induced Renal Injury in Chronic Kidney Disease

期刊: ANTIOXIDANTS & REDOX SIGNALING, ; ()

Aims: A high-salt diet can aggravate oxidative stress, and renal fibrosis via the brain and renal renin-angiotensin system (RAS) axis in chronic kidne......

Oxidative Stress-Induced Hypermethylation of KLF5 Promoter Mediated by DNMT3B Impairs Osteogenesis by Diminishing the Interaction with beta-Catenin

期刊: ANTIOXIDANTS & REDOX SIGNALING, ; ()

Aims: Emerging evidence suggests that the pathogenesis of osteoporosis, characterized by impaired osteogenesis, is shifting from estrogen centric to o......

Activity-Induced SUMOylation of Neuronal Nitric Oxide Synthase Is Associated with Plasticity of Synaptic Transmission and Extracellular Signal-Regulated Kinase 1/2 Signaling

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (1)

Aims: Neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) signaling have been implicated in learning, memory, and underlying long-lasting syna......

Carbon Monoxide Inhibits T Cell Proliferation by Suppressing Reactive Oxygen Species Signaling

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (7)

Aims: Carbon monoxide (CO) confers antiproliferative effects on T cells; however, how these effects are produced remains unclear. Reactive oxygen spec......

SOD3 Is Secreted by Adipocytes and Mitigates High-Fat Diet-Induced Obesity, Inflammation, and Insulin Resistance

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (3)

Aims: To study the expression and regulatory role of SOD3 in adipocytes and adipose tissue. Results: SOD3 expression was determined in various tissues......

Golgi Stress Response, Hydrogen Sulfide Metabolism, and Intracellular Calcium Homeostasis

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (9)

Aims: The physiological and pathological importance of hydrogen sulfide (H2S) as a novel gasotransmitter has been widely recognized. Cystathionine gam......

Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (10)

Critical Issues: Glutaredoxins mainly catalyze the removal of protein-bound GSH and help maintain protein thiols in a highly reduced state without exe......

Anti-Allergic and Anti-Inflammatory Effects and Molecular Mechanisms of Thioredoxin on Respiratory System Diseases

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (11)

Recent Advances: We demonstrated that systemic administration and transgenic overexpression of TRX is useful in a wide variety of in vivo inflammatory......

Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 33 (5)

Recent Advances: Recently, the strategy for neurodegenerative disease therapy has shifted from the use of antioxidants and conventional anti-inflammat......

Obesity-Induced Regulator of Calcineurin 1 Overexpression Leads to beta-Cell Failure Through Mitophagy Pathway Inhibition

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (7)

Aims: Type 2 diabetes (T2D) is associated with pancreatic beta-cell dysfunction, manifested by reduced glucose-stimulated insulin secretion (GSIS). Th......

Myeloperoxidase As a Multifaceted Target for Cardiovascular Protection

期刊: ANTIOXIDANTS & REDOX SIGNALING, 2020; 32 (15)

Recent Advances: Several studies have shown a strong correlation between MPO and cardiovascular disease (CVD), through which elevated levels of circul......

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