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Genome wide association study identifies four loci for early onset schizophrenia

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Early onset schizophrenia (EOS, defined as first onset of schizophrenia before age 18) is a rare form of schizophrenia (SCZ). Though genome-wide assoc......

Mindfulness practice for protecting mental health during the COVID-19 pandemic

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Emerging evidence shows that the coronavirus disease 2019 (COVID-19) pandemic is negatively affecting mental health around the globe. Interventions to......

Are psychiatric disorders risk factors for COVID-19 susceptibility and severity? a two-sample, bidirectional, univariable, and multivariable Mendelian Randomization study

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Observational studies have suggested bidirectional associations between psychiatric disorders and COVID-19 phenotypes, but results of such studies are......

Psychological responses among nurses caring for patients with COVID-19: a comparative study in China

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Frontline healthcare nurses devoted themselves to deal with the outbreak of COVID-19, saving many lives. However, they are under incredible unknown ps......

Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

To assess plasma phosphorylated tau181 (p-tau181) as a progression biomarker in Alzheimer's disease (AD), we examined longitudinal plasma p-tau181 of ......

Cortisol and inflammatory biomarker levels in youths with attention deficit hyperactivity disorder (ADHD): evidence from a systematic review with meta-analysis

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Several studies reported abnormal cortisol and inflammatory biomarker levels in youths with attention deficit hyperactivity disorder (ADHD), but the r......

The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

A growing number of studies have shown that brain-derived neurotrophic factor (BDNF) is associated with weight gain during antipsychotic treatment in ......

Polygenic risk score, healthy lifestyles, and risk of incident depression

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Genetic factors increase the risk of depression, but the extent to which this can be offset by modifiable lifestyle factors is unknown. We investigate......

Hippocampal PGC-1 alpha-mediated positive effects on parvalbumin interneurons are required for the antidepressant effects of running exercise

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Running exercise was shown to have a positive effect on depressive-like symptoms in many studies, but the underlying mechanism of running exercise in ......

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have ident......

Ahi1 regulates the nuclear translocation of glucocorticoid receptor to modulate stress response

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Stress activates the nuclear translocation of glucocorticoid receptors (GR) to trigger gene expression. Abnormal GR levels can alter the stress respon......

miR-98-5p plays a critical role in depression and antidepressant effect of ketamine

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Ketamine has been demonstrated to be a rapid-onset and long-lasting antidepressant, but its underlying molecular mechanisms remain unclear. Recent stu......

Prevalence of poor psychiatric status and sleep quality among frontline healthcare workers during and after the COVID-19 outbreak: a longitudinal study

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Poor psychiatric status and sleep quality were common among frontline healthcare workers (FHWs) during the outbreak of the 2019 novel coronavirus dise......

Understanding the psychiatric symptoms of COVID-19: a meta-analysis of studies assessing psychiatric symptoms in Chinese patients with and survivors of COVID-19 and SARS by using the Symptom Checklist-90-Revised

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Understanding the psychiatric symptoms of COVID-19 could facilitate the clinical management of COVID-19 patients. However, the profile of psychiatric ......

Intrauterine hyperglycemia impairs memory across two generations

期刊: TRANSLATIONAL PSYCHIATRY, 2021; 11 (1)

Studies on humans and animals suggest associations between gestational diabetes mellitus (GDM) with increased susceptibility to develop neurological d......

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