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Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (7)

Aims Spontaneous coronary artery dissection (SCAD) is a cause of acute coronary syndromes and in rare cases sudden cardiac death (SCD). Connective tis......

JIF:5.353

Chronically elevated branched chain amino acid levels are pro-arrhythmic

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (7)

Aims Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac fa......

JIF:5.353

Risk factors profile of young and older patients with myocardial infarction

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (10)

Myocardial infarction (MI) among young adults (<45 years) represents a considerable proportion of the total heart attack incidents. The underlying ......

JIF:5.353

Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (9)

Aims Atrial fibrillation (AF) is associated with higher mortality. Biomarkers may improve the understanding of key pathophysiologic processes in AF th......

JIF:5.353

Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (11)

Aims Sepsis-induced lung injury is associated with significant morbidity and mortality. Previously, we showed that heterozygous deletion of polymerase......

JIF:5.353

TNAP as a therapeutic target for cardiovascular calcification: a discussion of its pleiotropic functions in the body

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (1)

Cardiovascular calcification (CVC) is associated with increased morbidity and mortality. It develops in several diseases and locations, such as in the......

JIF:5.353

Loss of myeloid cell-specific SIRP alpha, but not CD47, attenuates inflammation and suppresses atherosclerosis

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (15)

Aims Inhibitors of the anti-phagocytic CD47-SIRP alpha immune checkpoint are currently in clinical development for a variety of haematological and sol......

JIF:5.353

Cardiac SARS-CoV-2 infection is associated with pro-inflammatory transcriptomic alterations within the heart

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (2)

Aims Cardiac involvement in COVID-19 is associated with adverse outcome. However, it is unclear whether cell-specific consequences are associated with......

JIF:5.353

Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact

期刊: CARDIOVASCULAR RESEARCH, 2022; 118 (15)

Aims A mutation in the phospholamban (PLN) gene, leading to deletion of Arg14 (R14del), has been associated with malignant arrhythmias and ventricular......

JIF:5.353

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