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Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson's disease

期刊: AGING CELL, 2022; 21 (5)

Substantial spine loss in striatal medium spiny neurons (MSNs) and abnormal behaviors are common features of Parkinson's disease (PD). The caudate put......

JIF:7.899

Accumulation of systematic TPM1 mediates inflammation and neuronal remodeling by phosphorylating PKA and regulating the FABP5/NF-kappa B signaling pathway in the retina of aged mice

期刊: AGING CELL, 2022; 21 (3)

The molecular mechanisms underlying functional decline during normal brain aging are poorly understood. Here, we identified the actin-associated prote......

JIF:7.899

Inhibition of DNA methyltransferase aberrations reinstates antioxidant aging suppressors and ameliorates renal aging

期刊: AGING CELL, 2022; 21 (1)

DNA methylation alterations play mechanistic roles in aging; however, the epigenetic regulators/mediators causally involved in renal aging remain elus......

JIF:7.899

Age-related DNA methylation on Y chromosome and their associations with total mortality among Chinese males

期刊: AGING CELL, 2022; 21 (3)

In view of the sex differences in aging-related diseases, sex chromosomes may play a critical role during aging process. This study aimed to identify ......

JIF:7.899

Arolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: Involvement of RhoA/ROCK2 pathway

期刊: AGING CELL, 2022; 21 (4)

Acrolein, an unsaturated aldehyde, is increased in the brain of Alzheimer's disease (AD) patients and identified as a potential inducer of sporadic AD......

JIF:7.899

Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription

期刊: AGING CELL, 2022; 21 (5)

Aberrant increases in neuronal network excitability may contribute to cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlyi......

JIF:7.899

Age-related memory vulnerability to interfering stimuli is caused by gradual loss of MAPK-dependent protection in Drosophila

期刊: AGING CELL, 2022; 21 (6)

Age-related memory impairment (AMI) is a common phenomenon across species. Vulnerability to interfering stimuli has been proposed to be an important c......

JIF:7.899

Fusion and expansion of vitellogenin vesicles during Caenorhabditis elegans intestinal senescence

期刊: AGING CELL, 2022; 21 (11)

Some of the most conspicuous aging phenotypes of C. elegans are related to post-reproductive production of vitellogenins (Vtg), which form yolk protei......

JIF:7.899

Physiological clearance of A beta by spleen and splenectomy aggravates Alzheimer-type pathogenesis

期刊: AGING CELL, 2022; 21 (1)

Background A previous study demonstrated that nearly 40%-60% of brain A beta flows out into the peripheral system for clearance. However, where and ho......

JIF:7.899

Loss of legumain induces premature senescence and mediates aging-related renal fibrosis

期刊: AGING CELL, 2022; 21 (3)

Aging is an independent risk factor for acute kidney injury and subsequent chronic kidney diseases, while the underlying mechanism is still elusive. H......

JIF:7.899

Ipriflavone as a non-steroidal glucocorticoid receptor antagonist ameliorates diabetic cognitive impairment in mice

期刊: AGING CELL, 2022; 21 (3)

Diabetic cognitive impairment (DCI) is a common diabetic complication with hallmarks of loss of learning ability and disorders of memory and behavior.......

JIF:7.899

Alzheimer-like tau accumulation in dentate gyrus mossy cells induces spatial cognitive deficits by disrupting multiple memory-related signaling and inhibiting local neural circuit

期刊: AGING CELL, 2022; 21 (5)

Abnormal tau accumulation and spatial memory loss constitute characteristic pathology and symptoms of Alzheimer disease (AD). Yet, the intrinsic conne......

JIF:7.899

Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

期刊: AGING CELL, 2022; 21 (6)

Macrophage-stimulator of interferon genes (STING) signaling mediated sterile inflammation has been implicated in various age-related diseases. However......

JIF:7.899

Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3 epsilon to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells

期刊: AGING CELL, 2022; 21 (9)

Stem cell senescence is an important cause of aging. Delaying senescence may present a novel way to combat aging and age-associated diseases. This stu......

JIF:7.899

Fibronectin type III domain-containing 5 improves aging-related cardiac dysfunction in mice

期刊: AGING CELL, 2022; 21 (3)

Aging is an important risk factor for cardiovascular diseases, and aging-related cardiac dysfunction serves as a major determinant of morbidity and mo......

JIF:7.899

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