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Altered synaptic connectivity in an in vitro human model of STXBP1 encephalopathy

期刊: BRAIN, 2023; 146 (3)

Early infantile developmental and epileptic encephalopathies are devastating conditions, generally of genetic origin, but the pathological mechanisms ......

Multimodal layer modelling reveals in vivo pathology in amyotrophic lateral sclerosis

期刊: BRAIN, 2023; ()

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the loss of motor control. Current understandi......

Intact finger representation within primary sensorimotor cortex of musician's dystonia

期刊: BRAIN, 2023; 146 (4)

Sadnicka et al. counter the idea that task-specific dystonia is the result of a disordered hand somatotopy in S1. They suggest that the representation......

Genetically identical twin-pair difference models support the amyloid cascade hypothesis

期刊: BRAIN, 2023; 146 (9)

The amyloid cascade hypothesis has strongly impacted the Alzheimer's disease research agenda and clinical trial designs over the past decades, but pre......

A critical brainstem relay for mediation of diffuse noxious inhibitory controls

期刊: BRAIN, 2023; 146 (6)

Diffuse noxious inhibitory control is a phenomenon whereby one noxious stimulus can inhibit the pain response to another. Kucharczyk et al. identify t......

Negative symptoms, striatal dopamine and model-free reward decision-making in schizophrenia

期刊: BRAIN, 2023; 146 (2)

Negative symptoms, such as lack of motivation or social withdrawal, are highly prevalent and debilitating in patients with schizophrenia. Underlying m......

Social cognition deficits and biometric signatures in the behavioural variant of Alzheimer's disease

期刊: BRAIN, 2023; 146 (5)

The behavioural variant of Alzheimer's disease (bvAD) is characterized by early predominant behavioural changes, mimicking the behavioural variant of ......

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