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Long Noncoding RNA Ahit Protects Against Cardiac Hypertrophy Through SUZ12 (Suppressor of Zeste 12 Protein Homolog)-Mediated Downregulation of MEF2A (Myocyte Enhancer Factor 2A)

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (1)

BACKGROUND: Long noncoding RNA (lncRNA) can regulate various physiological and pathological processes through multiple molecular mechanisms in cis and......

Pharmacological Silencing of MicroRNA-152 Prevents Pressure Overload-Induced Heart Failure

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (3)

Background: MicroRNAs are small, noncoding RNAs that play a key role in gene expression. Accumulating evidence suggests that aberrant microRNA express......

Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (7)

Background: NEXN (nexilin) is a protein of the junctional membrane complex required for development of cardiac T-tubules. Global and cardiomyocyte-spe......

COP9 Signalosome Suppresses RIPK1-RIPK3-Mediated Cardiomyocyte Necroptosis in Mice

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (8)

BACKGROUND: Mechanisms governing the induction of heart failure by the impairment of autophagy and the ubiquitin-proteasome system and the molecular p......

Prognostic Value of Secreted Frizzled-Related Protein 5 in Heart Failure Patients With and Without Type 2 Diabetes Mellitus

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (9)

Background: Patients with heart failure (HF) with diabetes mellitus have distinct biomarker profiles compared with those without diabetes mellitus. SF......

Referral Criteria to Palliative Care for Patients With Heart Failure A Systematic Review

期刊: CIRCULATION-HEART FAILURE, 2020; 13 (9)

Background: Patients with heart failure have significant symptom burden, care needs, and often a progressive course to end-stage disease. Palliative c......

Decreased KCNE2 Expression Participates in the Development of Cardiac Hypertrophy by Regulation of Calcineurin-NFAT (Nuclear Factor of Activated T Cells) and Mitogen-Activated Protein Kinase Pathways

期刊: CIRCULATION-HEART FAILURE, 2017; 10 (6)

Background-KCNE2 is a promiscuous auxiliary subunit of voltage-gated cation channels. A recent work demonstrated that KCNE2 regulates L-type Ca2+ chan......

JIF:5.68

Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure

期刊: CIRCULATION-HEART FAILURE, 2017; 10 (7)

BACKGROUND: Lysosomal dysfunction is implicated in human heart failure for which ischemic heart disease is the leading cause. Altered myocardial expre......

JIF:5.68

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