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Pharmacokinetics and Molecular Modeling Indicate nAChR alpha 4-Derived Peptide HAEE Goes through the Blood-Brain Barrier

期刊: BIOMOLECULES, 2021; 11 (6)

One of the treatment strategies for Alzheimer's disease (AD) is based on the use of pharmacological agents capable of binding to beta-amyloid (A beta)......

From the Identification to the Dissection of the Physiological Role of the Mitochondrial Calcium Uniporter: An Ongoing Story

期刊: BIOMOLECULES, 2021; 11 (6)

The notion of mitochondria being involved in the decoding and shaping of intracellular Ca2+ signals has been circulating since the end of the 19th cen......

Leptin Is Associated with Poor Clinical Outcomes and Promotes Clear Cell Renal Cell Carcinoma Progression

期刊: BIOMOLECULES, 2021; 11 (3)

Emerging evidence has shown the oncogenic roles of leptin in modulating cancer progression in addition to its original roles. Analyses of transcriptom......

Effect of You-Gui-Wan on House Dust Mite-Induced Mouse Allergic Asthma via Regulating Amino Acid Metabolic Disorder and Gut Dysbiosis

期刊: BIOMOLECULES, 2021; 11 (6)

Chinese herbal remedies have long been used for enhancing immunity and treating asthma. However, the evidence-based efficacy remains to be supported. ......

Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers

期刊: BIOMOLECULES, 2021; 11 (7)

Epithelial Protein Lost In Neoplasm (EPLIN), also known as LIMA1 (LIM Domain And Actin Binding 1), was first discovered as a protein differentially ex......

Benefits of Metformin Combined with Pemetrexed-Based Platinum Doublets as a First-Line Therapy for Advanced Lung Adenocarcinoma Patients with Diabetes

期刊: BIOMOLECULES, 2021; 11 (8)

Lung cancer remains a challenge in daily practice. Chemotherapy is first considered for advanced lung adenocarcinoma bearing no active driver mutation......

S100P Interacts with p53 while Pentamidine Inhibits This Interaction

期刊: BIOMOLECULES, 2021; 11 (5)

S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. It has been hypothesized that the oncogenic function......

Co-Therapy of Albendazole and Dexamethasone Reduces Pathological Changes in the Cerebral Parenchyma of Th-1 and Th-2 Dominant Mice Heavily Infected with Angiostrongylus cantonensis: Histopathological and RNA-seq Analyses

期刊: BIOMOLECULES, 2021; 11 (4)

Administration of albendazole alone was not very suitable for the treatment of cerebral angiostrongyliasis. This study was designed to evaluate the ef......

Immobilized Soybean Peroxidase Hybrid Biocatalysts for Efficient Degradation of Various Emerging Pollutants

期刊: BIOMOLECULES, 2021; 11 (6)

In the present study, soybean peroxidase (SBP) was covalently immobilized onto two functionalized photocatalytic supports (TiO2 and ZnO) to create nov......

Exogenously Applied Gibberellic Acid Enhances Growth and Salinity Stress Tolerance of Maize through Modulating the Morpho-Physiological, Biochemical and Molecular Attributes

期刊: BIOMOLECULES, 2021; 11 (7)

Soil salinity is the major limiting factor restricting plant growth and development. Little is known about the comparative and combined effects of gib......

The Role of Hydrogen Sulfide in Respiratory Diseases

期刊: BIOMOLECULES, 2021; 11 (5)

Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory di......

Amelioration of Chlorpyrifos-Induced Toxicity in Brassica juncea L. by Combination of 24-Epibrassinolide and Plant-Growth-Promoting Rhizobacteria

期刊: BIOMOLECULES, 2021; 11 (6)

Pervasive use of chlorpyrifos (CP), an organophosphorus pesticide, has been proven to be fatal for plant growth, especially at higher concentrations. ......

Sphingosine Promotes Embryo Biomass in Upland Cotton: A Biochemical and Transcriptomic Analysis

期刊: BIOMOLECULES, 2021; 11 (4)

Sphingolipids are essential membrane components and signal molecules, but their regulatory role in cotton embryo growth is largely unclear. In this st......

Repositioning Azelnidipine as a Dual Inhibitor Targeting CD47/SIRP alpha and TIGIT/PVR Pathways for Cancer Immuno-Therapy

期刊: BIOMOLECULES, 2021; 11 (5)

Strategies boosting both innate and adaptive immunity have great application prospects in cancer immunotherapy. Antibodies dual blocking the innate ch......

Engineering the Vasculature of Stem-Cell-Derived Liver Organoids

期刊: BIOMOLECULES, 2021; 11 (7)

The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids ......

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