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Histone H2A deubiquitinases in the transcriptional programs of development and hematopoiesis: a consolidated analysis

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 157 ()

Monoubiquitinated lysine 119 of histone H2A (H2AK119ub) is a highly abundant epigenetic mark, associated with gene repression and deposited on chromat......

Reduced sulfatide content in deferoxamine-induced senescent HepG2 cells

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 159 ()

Iron chelators, such as deferoxamine, exert an anticancer effect by altering the activity of biomolecules critical for regulation of the cell cycle, c......

Mitochondria and the cell cycle in budding yeast

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 161 ()

As centers for energy production and essential biosynthetic activities, mitochondria are vital for cell growth and proliferation. Accumulating evidenc......

Role of innate lymphoid cells in cancer metastasis

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 163 ()

Metastatic spread of cancer accounts for most cancer-related deaths. Cancer seeding in secondary organs requires reprogramming of the local stromal an......

Regulation of human ZNF687, a gene associated with Paget's disease of bone

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 154 ()

Mutations in Zinc finger 687 (ZNF687) were associated with Paget's disease of bone (PDB), a disease charac-terized by increased bone resorption and ex......

Nicotinic acetylcholine receptors: Key targets for attenuating neurodegenerative diseases

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 157 ()

Nicotinic acetylcholine receptors (nAChRs) are master regulators of immune functions via the cholinergic anti-inflammatory pathway and are expressed i......

CRISPR activation and interference as investigative tools in the cardiovascular system

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 155 ()

CRISPR activation and interference (CRISPRa/i) technology offers the unprecedented possibility of achieving regulated gene expression both in vitro an......

Inhibition of histone lysine demethylase 6A promotes chondrocytic activity and attenuates osteoarthritis development through repressing H3K27me3 enhancement of Wnt10a

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 158 ()

Histone hypermethylation represses gene transcription, which affects cartilage homeostasis or joint remodeling. Trimethylation of lysine 27 of histone......

Molecular profiling in desmoplastic small round cell tumours

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 157 ()

Desmoplastic small round cell tumour (DSRCT) is an ultra-rare soft tissue sarcoma that is characterised by aggressive disease and dismal patient outco......

Large-scale expanded sample imaging with tiling lattice lightsheet microscopy

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 154 ()

The ability to observe biological nanostructures forms a vital step in understanding their functions. Thanks to the invention of expansion microscopy ......

Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 162 ()

The faithful splicing of pre-mRNA is critical for accurate gene expression. Dysregulation of pre-mRNA splicing has been associated with several human ......

LARP4A and LARP4B in cancer: The new kids on the block

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 161 ()

Recent developments have mounted a stunning body of evidence underlying the importance of RNA binding proteins (RBPs) in cancer research. In this mini......

The role of monocyte-derived macrophages in the lung: It's all about context

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 159 ()

Macrophages are present in every tissue of the body where they play crucial roles in maintaining tissue homeostasis and providing front line defence a......

Mitochondria are midfield players in steroid synthesis

期刊: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2023; 160 ()

Steroids are important membrane components and signaling metabolites and thus are required for cellular ho-meostasis. All mammalian cells retain the a......

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