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Computational modeling of aberrant electrical activity following remuscularization with intramyocardially injected pluripotent stem cell-derived cardiomyocytes

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 162 ()

Acute engraftment arrhythmias (EAs) remain a serious complication of remuscularization therapy. Preliminary evidence suggests that a focal source unde......

JIF:4.275

NAFLD as a continuous driver in the whole spectrum of vascular disease

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 163 ()

Vascular disease is the prime determinant to cardiovascular morbidities and mortalities, which comprises the early vascular damage and subsequent card......

JIF:4.275

Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 164 ()

Aged males disproportionately succumb to increased COVID-19 severity, hospitalization, and mortality compared to females. Angiotensin-converting enzym......

JIF:4.275

Advances in three-dimensional bioprinted stem cell-based tissue engineering for cardiovascular regeneration

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 169 ()

Three-dimensional (3D) bioprinting of cellular or biological components are an emerging field to develop tissue structures that mimic the spatial, mec......

JIF:4.275

Elucidating the role of the L-type calcium channel in excitability and energetics in the heart: The ISHR 2020 Research Achievement Award Lecture

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 172 ()

Cardiovascular disease continues to be the leading health burden worldwide and with the rising rates in obesity and type II diabetes and ongoing effec......

JIF:4.275

Improved nanopore direct RNA sequencing of cardiac myocyte samples by selective mt-RNA depletion

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 163 ()

RNA sequencing is a powerful tool to analyze gene expression transcriptome wide. However, RNA sequencing in general and especially the recently develo......

JIF:4.275

Single cardiomyocytes from papillary muscles show lower preload-dependent activation of force compared to cardiomyocytes from the left ventricular free wall

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 166 ()

Efficient pumping of the healthy left ventricle (LV) requires heterogeneities in mechanical function of individual cardiomyocytes (CM). Deformation of......

JIF:4.275

A perinuclear calcium compartment regulates cardiac myocyte hypertrophy

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 172 ()

The pleiotropic Ca2+/calmodulin-dependent phosphatase calcineurin is a key regulator of pathological cardiac myocyte hypertrophy. The selective activa......

JIF:4.275

Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 165 ()

Cyclic AMP is a ubiquitous second messenger used to transduce intracellular signals from a variety of Gs-coupled receptors. Compartmentalisation of pr......

JIF:4.275

Ventricular SK2 upregulation following angiotensin II challenge: Modulation by p21-activated kinase-1

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 164 ()

Effects of hypertrophic challenge on small-conductance, Ca2+-activated K+ (SK2) channel expression were explored in intact murine hearts, isolated ven......

JIF:4.275

Production of functional cardiomyocytes and cardiac tissue from human induced pluripotent stem cells for regenerative therapy

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 164 ()

The emergence of human induced pluripotent stem cells (hiPSCs) has revealed the potential for curing end-stage heart failure. Indeed, transplantation ......

JIF:4.275

Impaired CaV1.2 inactivation reduces the efficacy of calcium channel blockers in the treatment of LQT8

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 173 ()

Mutations in the CaV1.2 L-type calcium channel can cause a profound form of long-QT syndrome known as longQT type 8 (LQT8), which results in cardiac a......

JIF:4.275

Minimally invasive delivery of a hydrogel-based exosome patch to prevent heart failure

期刊: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2022; 169 ()

Coronary heart disease (CHD) has been the number one killer in the United States for decades and causes millions of deaths each year. Clinical treatme......

JIF:4.275

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