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Senescence and aging of solid organs? Blame the immune system!

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, 2021; 21 (8)

Senescence and aging of immune cells drive systemic aging and age-related organ injuries.

Breaking the NF-kB barriers to promote interspecies organogenesis

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, 2021; 21 (5)

Activation of the NF-kB pathway mediates apoptotic cell death of human stem cells during interspecies stem cell competition.

Luminal polyethylene glycol solution delays the onset of preservation injury in the human intestine

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, ; ()

The organ damage incurred during the cold storage (CS) of intestinal grafts has short and long-term consequences. Animal studies suggest that addition......

An early experience on the effect of solid organ transplant status on hospitalized COVID-19 patients

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, ; ()

We compared the outcome of COVID-19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naive population. In total, 10 356 adult......

Circular RNA Foxo3 in cardiac ischemia-reperfusion injury in heart transplantation: A new regulator and target

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, ; ()

Ischemia-reperfusion (I/R) injury occurring in heart transplantation (HT) remains as a leading cause of transplant heart graft failure. Circular RNAs ......

Donor genetic variants as risk factors for thrombosis after liver transplantation: A genome-wide association study

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, ; ()

Thrombosis after liver transplantation substantially impairs graft- and patient survival. Inevitably, heritable disorders of coagulation originating i......

A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, ; ()

Complement is known to play a role in ischemia and reperfusion injury (IRI). A general paradigm is that complement is activated by self-reactive natur......

The entangled world of T cell memory and exhaustion

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, 2021; 21 (2)

T cell memory and exhaustion develop in parallel under physiological conditions constituting a normal memory repertoire.

T cell exhaustion is associated with antigen abundance and promotes transplant acceptance

期刊: AMERICAN JOURNAL OF TRANSPLANTATION, 2020; 20 (9)

Exhaustion of T cells limits their ability to clear chronic infections or eradicate tumors. Here, in the context of transplant, we investigated whethe......

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