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Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (4)

Post-traumatic stress disorder (PTSD) is characterized by depression/anxiety and memory failure, primarily fear memory. According to the reports, neur......

Spinal Nrf2 translocation may inhibit neuronal NF-kappa B activation and alleviate allodynia in a rat model of bone cancer pain

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (5)

Bone cancer pain (BCP) is a clinical pathology that urgently needs to be solved, but research on the mechanism of BCP has so far achieved limited succ......

Progranulin in neurodegenerative dementia

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (2)

Long-term or severe lack of protective factors is important in the pathogenesis of neurodegenerative dementia. Progranulin (PGRN), a neurotrophic fact......

Activation of spinal PDGFR beta in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (2)

The adverse side effects of opioids, especially antinociceptive tolerance, limit their clinical application. A recent study reported that platelet-der......

MicroRNA-124-3p attenuates the development of nerve injury-induced neuropathic pain by targeting early growth response 1 in the dorsal root ganglia and spinal dorsal horn

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (4)

Emerging evidence indicates the early growth response 1 (Egr1) plays an important role in the pathogenesis of chronic pain. However, the regulation of......

Flavonoid fisetin reverses impaired hippocampal synaptic plasticity and cognitive function by regulating the function of AMPARs in a male rat model of schizophrenia

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (2)

Cognitive deficits are the core feature of schizophrenia and effective treatment strategies are still missing. Previous studies have reported that fis......

Ponesimod protects against neuronal death by suppressing the activation of A1 astrocytes in early brain injury after experimental subarachnoid hemorrhage

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (4)

As an important initiator and responder of brain inflammation in the central nervous system (CNS), astrocytes transform into two new reactive phenotyp......

The adenosine A(2A) receptor alleviates postoperative delirium-like behaviors by restoring blood cerebrospinal barrier permeability in rats

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (4)

Postoperative delirium (POD) is a common post-operative complication in elderly patients that is associated with increased morbidity and mortality. Ho......

Wolfberry-derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (5)

Retinitis pigmentosa (RP) is a group of inherited photoreceptor degeneration diseases that causes blindness without effective treatment. The pathogene......

The human brain acetylome reveals that decreased acetylation of mitochondrial proteins associates with Alzheimer's disease

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (2)

Metabolic changes that correlate to cognitive changes are well-known in Alzheimer's disease (AD). Metabolism is often linked to functional changes in ......

Phosphorylation of trans-active response DNA-binding protein-of 43 kDa promotes its cytoplasmic aggregation and modulates its function in tau mRNA stability and exon 10 alternative splicing

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (3)

Trans-active response DNA-binding protein of 43 kDa (TDP-43) promotes tau mRNA instability and tau exon 10 inclusion. Aggregation of phosphorylated TD......

Toll-like receptor 2 activation and up-regulation by high mobility group box-1 contribute to post-operative neuroinflammation and cognitive dysfunction in mice

期刊: JOURNAL OF NEUROCHEMISTRY, 2021; 158 (2)

Post-operative cognitive dysfunction (POCD) is common and is associated with poor clinical outcome. Toll-like receptor (TLR) 3 and 4 have been implied......

The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules

期刊: JOURNAL OF NEUROCHEMISTRY, ; ()

Phospholipid Phosphatase-Related Protein Type 1 (PLPPR1) is a member of a family of lipid phosphatase related proteins, integral membrane proteins cha......

Exosomes in Parkinson disease

期刊: JOURNAL OF NEUROCHEMISTRY, ; ()

Parkinson disease (PD) is a prevalent neurodegenerative disease, in which the formation of misfolded and aggregated alpha-synuclein is a key neuropath......

Clusterin inhibits A beta(42) aggregation through a "strawberry model" as detected by FRET-FCS

期刊: JOURNAL OF NEUROCHEMISTRY, ; ()

Extracellular plaque deposits of beta-amyloid peptide (A beta) are one of the main pathological features of Alzheimer's disease (AD), The aggregation ......

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