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Exosomal AP000439.2 from clear cell renal cell carcinoma induces M2 macrophage polarization to promote tumor progression through activation of STAT3

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: Tumorigenic phenotype of M2 tumor-associated macrophages promote tumor progression in response to exosomes cues imposed by tumor cells. Ho......

JIF:5.128

The regulatory role of NAAG-mGluR3 signaling on cortical synaptic plasticity after hypoxic ischemia

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: Synapses can adapt to changes in the intracerebral microenvironment by regulation of presynaptic neurotransmitter release and postsynaptic......

JIF:5.128

tRF-Val-CAC-016 modulates the transduction of CACNA1d-mediated MAPK signaling pathways to suppress the proliferation of gastric carcinoma

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: As a new kind of non-coding RNAs (ncRNAs), tRNA derivatives play an important role in gastric carcinoma (GC). Nevertheless, the underlying......

JIF:5.128

TGF-beta 1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: The transforming growth factor-beta (TGF-beta) signaling pathway is an important pathway associated with the pathogenesis of osteoarthriti......

JIF:5.128

Apoptin mediates mitophagy and endogenous apoptosis by regulating the level of ROS in hepatocellular carcinoma

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: Apoptin, as a tumor-specific pro-apoptotic protein, plays an important anti-tumoral role, but its mechanism of autophagy activation and th......

JIF:5.128

Exosomes: the key of sophisticated cell-cell communication and targeted metastasis in pancreatic cancer

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Pancreatic cancer is one of the most common malignancies. Unfortunately, the lack of effective methods of treatment and diagnosis has led to poor prog......

JIF:5.128

Rhythm disturbance in osteoarthritis

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Osteoarthritis (OA) is one of the main causes of disabilities among older people. To date, multiple disease-related molecular networks in OA have been......

JIF:5.128

Cholecystectomy promotes colon carcinogenesis by activating the Wnt signaling pathway by increasing the deoxycholic acid level

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Purpose: Cholecystectomy (XGB) is widely recognized as a risk factor for colon cancer (CC). Continuous exposure of the colonic epithelium to deoxychol......

JIF:5.128

Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: N-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been imp......

JIF:5.128

Alternative autophagy: mechanisms and roles in different diseases

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

As an important mechanism to maintain cellular homeostasis, autophagy exerts critical functions via degrading misfolded proteins and damaged organelle......

JIF:5.128

Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: Transcription factor c-Myc plays a critical role in various physiological and pathological events. c-Myc gene rearrangement is closely ass......

JIF:5.128

CCL7 playing a dominant role in recruiting early OCPs to facilitate osteolysis at metastatic site of colorectal cancer

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: Chemoattractant is critical to recruitment of osteoclast precursors and stimulates tumor bone metastasis. However, the role of chemoattrac......

JIF:5.128

Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: As a class of the opioid receptors, the kappa opioid receptor (KOR) has been verified to be a potential biomarker and therapeutic target f......

JIF:5.128

Docetaxel suppressed cell proliferation through Smad3/HIF-1 alpha-mediated glycolysis in prostate cancer cells

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background:Tumor glycolysis is a critical event for tumor progression. Docetaxel is widely used as a first-line drug for chemotherapy and shown to hav......

JIF:5.128

Bioinformatic analysis and preliminary validation of potential therapeutic targets for COVID-19 infection in asthma patients

期刊: CELL COMMUNICATION AND SIGNALING, 2022; 20 (1)

Background: Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 19 (COVID-19). The number of confirmed cases of COVID-19 is als......

JIF:5.128

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