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Machine learning-based decision tree classifier for the diagnosis of progressive supranuclear palsy and corticobasal degeneration

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, ; ()

Aims This study aimed to clarify the different topographical distribution of tau pathology between progressive supranuclear palsy (PSP) and corticobas......

Myositis with sarcoplasmic inclusions in Nakajo-Nishimura syndrome: a genetic inflammatory myopathy

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2020; 46 (6)

Aims: Nakajo-Nishimura syndrome (NNS) is an autosomal recessive disease caused by biallelic mutations in the PSMB8 gene that encodes the immunoproteas......

NLRP3 inflammasome and endoplasmic reticulum stress in the epileptogenic zone in temporal lobe epilepsy: molecular insights into their interdependence

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2020; 46 (7)

Aim Nod-like receptor protein 3 (NLRP3) inflammasome-mediated inflammation has emerged as a contributor to epileptogenesis. Endoplasmic reticulum stre......

Baseline concentration of misfolded alpha-synuclein aggregates in cerebrospinal fluid predicts risk of cognitive decline in Parkinson's disease

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2019; 45 (4)

Background The prognostic significance of misfolded alpha-synuclein (alpha-Syn) aggregates in Parkinson's disease (PD) has not been well investigated.......

JIF:6.88

Pathoarchitectonics of the cerebral cortex in chorea-acanthocytosis and Huntington's disease

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2019; 45 (3)

Aims Quantitative estimation of cortical neurone loss in cases with chorea-acanthocytosis (ChAc) and its impact on laminar composition. Methods We use......

JIF:6.88

Mechanisms of ischaemic neural progenitor proliferation: a regulatory role of the HIF-1 alpha-CBX7 pathway

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 0; ()

Aims Investigations of the molecular mechanisms of hypoxia- and ischaemia-induced endogenous neural progenitor cell (NPC) proliferation have mainly fo......

Dock1 promotes the mesenchymal transition of glioma and is modulated by MiR-31

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2017; 43 (5)

AimsThis research aimed to examine the relationship between Dock1 and miR-31 and to determine the effect of miR-31 on the mesenchymal transition and i......

JIF:6.06

CD47 promotes the proliferation and migration of adamantinomatous craniopharyngioma cells by activating the MAPK/ERK pathway, and CD47 blockade facilitates microglia-mediated phagocytosis

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2022; 48 (4)

Aims CD47 is overexpressed in multiple tumours and plays an important role in immune escape and other biological processes of tumours. However, its ro......

JIF:5.4

Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5xFAD mouse model of Alzheimer's disease

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2022; 48 (7)

Aims Abundant recent evidence has shown that 3-phosphoinositide-dependent protein kinase 1 (PDK1) is activated in Alzheimer's disease (AD). However, i......

JIF:5.4

Molecular landscape of IDH-wild-type, H3-wild-type glioblastomas of adolescents and young adults

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2022; 48 (4)

Objective We aimed to characterise glioblastomas of adolescents and young adults (AYAs) that were isocitrate dehydrogenase (IDH) wild type (wt) and H3......

JIF:5.4

Comprehensive analysis of intratumoural heterogeneity of somatic copy number alterations in diffuse glioma reveals clonality-dependent prognostic patterns

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2022; 48 (6)

Aims Intratumoural heterogeneity (ITH) has been implicated in tumour growth and progression as well as therapy resistance. However, the extent of ITH ......

JIF:5.4

Investigating key factors underlying neurodegeneration linked to alpha-synuclein spread

期刊: NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2022; 48 (6)

Aims It has long been considered that accumulation of pathological alpha-synuclein (aSyn) leads to synaptic/neuronal loss which then results in behavi......

JIF:5.4

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