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Interleukin-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (3)

Streptococcus pneumoniae co-infection post-influenza is a major cause of mortality characterized by uncontrolled bacteria burden and excessive immune ......

Double-negative (DN) B cells: an under-recognized effector memory B cell subset in autoimmunity

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (2)

Human B cells could be divided into four classical subsets based on CD27 and immunoglobulin (Ig)D expression. Distinct from the other three well-studi......

Bone marrow-derived mesenchymal stem cells inhibit CD8(+) T cell immune responses via PD-1/PD-L1 pathway in multiple myeloma

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (1)

High expression of the inhibitory receptor programmed cell death ligand 1 (PD-L1) on tumor cells and tumor stromal cells have been found to play a key......

Nuclear factor kappa B inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 206 (1)

Guillain-Barre syndrome (GBS) is an acute inflammatory and immune-mediated demyelinating disease of the peripheral nervous system (PNS). Macrophages p......

Establishment of a novel double-monoclonal antibody sandwich enzyme-linked immunosorbent assay (ELISA): tool for human B7-H4 detection in autoimmune diseases

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (2)

B7-H4, one of the immunoregulatory proteins, plays an inhibitory role by inhibiting T cell proliferation and cytokine production. Nevertheless, the si......

Immune checkpoint inhibitors and cellular treatment for lymphoma immunotherapy

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (1)

Malignant lymphoma (ML) is a common hematological malignancy with many subtypes. Patients with ML usually undergo traditional treatment failure and be......

Differences in cytokine and chemokine profiles in cerebrospinal fluid caused by the etiology of cryptococcal meningitis and tuberculous meningitis in HIV patients

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 206 (1)

The roles of cytokines and chemokines in HIV-associated cryptococcal meningitis (HCM) and HIV-associated tuberculous meningitis (HTBM) are debatable. ......

Anti-CD47 antibody synergizes with cisplatin against laryngeal cancer by enhancing phagocytic ability of macrophages

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (3)

Cisplatin is mainly used in late-stage or recurrent laryngeal cancer patients. However, the effect of the chemotherapy is limited due to cisplatin res......

Prognostic implications of tumour-infiltrating lymphocytes for recurrence in epithelial ovarian cancer

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 206 (1)

The recurrence of patients with epithelial ovarian cancer (EOC) is largely attributed to tumour cells escaping from the surveillance of immune cells. ......

Anti-JMH alloantibody in inherited JMH-negative patients leads to immunogenic destruction of JMH-positive RBCs

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (2)

The clinical significance of the specific anti-John Milton Hagen (JMH) alloantibody in inherited JMH-negative patients remains unclear. During clinica......

A myriad of roles of dendritic cells in atherosclerosis

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 206 (1)

Atherosclerosis is an inflammatory disease with break-down of homeostatic immune regulation of vascular tissues. As a critical initiator of host immun......

Dynamic mRNA expression of donor-derived activating KIR genes and their significant effects on clinical outcome after haematopoietic stem cell transplantation

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (3)

Numerous reports suggest that activating killer immunoglobulin-like receptors (aKIRs) of natural killer (NK) cells, in addition to inhibitory KIRs (iK......

Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 205 (2)

Drugs and therapies available for the treatment of inflammatory bowel disease (IBD) are not satisfactory. Our previous study has established the inhib......

The prevalence of anti-neurofascin-155 antibodies in patients with neuromyelitis optica spectrum disorders

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2021; 206 (1)

Anti-neurofascin-155 (NF155) antibodies have been observed in two cases with neuromyelitis optica spectrum disorders (NMOSD). This study investigated ......

MiR-223-3p inhibits inflammation and pyroptosis in monosodium urate-induced rats and fibroblast-like synoviocytes by targeting NLRP3

期刊: CLINICAL AND EXPERIMENTAL IMMUNOLOGY, ; ()

Down-regulated miR-223-3p was found in rheumatoid arthritis. This study aimed to further explore the level and role of miR-223-3p in gout arthritis (G......

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