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Ferroptosis-related gene signature predicts prognosis and immunotherapy in glioma

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (8)

Aims Glioma is a highly invasive brain tumor, which makes prognosis challenging and renders patients resistant to various treatments. Induction of cel......

Normalization of non-canonical Wnt signalings does not compromise blood-brain barrier protection conferred by upregulating endothelial Wnt/beta-catenin signaling following ischemic stroke

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (9)

Background Endothelial canonical (Wnt/beta-catenin) and non-canonical Wnt signalings (Wnt/PCP and Wnt/Ca2+) promote blood-brain barrier (BBB) developm......

Neuroprotective effects and mechanisms of ischemic/hypoxic preconditioning on neurological diseases

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (8)

As the organ with the highest demand for oxygen, the brain has a poor tolerance to ischemia and hypoxia. Despite severe ischemia/hypoxia induces the o......

Prospects of antibodies targeting CD47 or CD24 in the treatment of glioblastoma

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (10)

Glioma is a malignant tumor with the highest incidence among all brain tumors (about 46% of intracranial tumors) and is the most common primary intrac......

Dorsal raphe serotonergic neurons promote arousal from isoflurane anesthesia

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (8)

Aims General anesthesia has been widely applied in surgical or nonsurgical medical procedures, but the mechanism behind remains elusive. Because of sh......

The role of NOTCH3 variants in Alzheimer's disease and subcortical vascular dementia in the Chinese population

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (8)

Aims NOTCH3 gene mutations predominantly cause cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, a common et......

Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (9)

Aims The blood-brain barrier (BBB) is a specialized and indispensable structure in brain blood vessels that is damaged during Alzheimer's disease (AD)......

TROAP regulates cell cycle and promotes tumor progression through Wnt/beta-Catenin signaling pathway in glioma cells

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (9)

Aims: Experimental evidence demonstrated a crucial role of TROAP (Trophinin-associated protein) in regulating the cell proliferation of multiple tumor......

Spinal microglial beta-endorphin signaling mediates IL-10 and exenatide-induced inhibition of synaptic plasticity in neuropathic pain

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (10)

Aim: This study aimed to investigate the regulation of pain hypersensitivity induced by the spinal synaptic transmission mechanisms underlying interle......

AIM2 deletion enhances blood-brain barrier integrity in experimental ischemic stroke

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (10)

Aims Ischemic stroke is a life-threatening disease with limited therapeutic strategies. Blood-brain barrier (BBB) disruption is a critical pathologica......

Establishment of a nomogram with EMP3 for predicting clinical outcomes in patients with glioma: A bi-center study

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (10)

Aim To demonstrate the clinical value of epithelial membrane protein 3 (EMP3) with bioinformatic analysis and clinical data, and then to establish a p......

Impact of beta-2 microglobulin expression on the survival of glioma patients via modulating the tumor immune microenvironment

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (8)

Aims High immune cell infiltration in gliomas establishes an immunosuppressive tumor microenvironment, which in turn promotes resistance to immunother......

Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (9)

Aim Spinal cord injury (SCI) involves multiple pathological processes. Ferroptosis has been shown to play a critical role in the injury process. We wa......

Recognition of seizure semiology and semiquantitative FDG-PET analysis of anti-LGI1 encephalitis

期刊: CNS NEUROSCIENCE & THERAPEUTICS, 2021; 27 (10)

Aims Anti-leucine-rich glioma-inactivated 1 (LGI1) autoimmune encephalitis (AE) is characterized by complex manifestations of seizures. Here, we repor......

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