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EasyNAT MP Assay: A Simple, Rapid, and Low-Cost Method to Detect Mycoplasma pneumoniae Using Cross-Priming Amplification Technology

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2022; 26 (3)

Background Mycoplasma pneumoniae (MP) is the most common pathogen of atypical pneumonia and the main cause of community-acquired pneumonia (CAP) in in......

JIF:3.364

Concordance Study of a 520-Gene Next-Generation Sequencing-Based Genomic Profiling Assay of Tissue and Plasma Samples

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2022; 26 (3)

Introduction Next-generation sequencing (NGS) enables simultaneous detection of actionable somatic variants and estimation of genomic signatures such ......

JIF:3.364

MET-Targeted Therapies and Clinical Outcomes: A Systematic Literature Review

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2022; 26 (2)

Introduction Numerous therapeutic agents specifically targeting the mesenchymal-epithelial transition (MET) oncogene are being developed. Objective Th......

JIF:3.364

Effect of E-cadherin on Prognosis of Colorectal Cancer: A Meta-Analysis Update

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2022; 26 (4)

Purpose The effect of E-cadherin on colorectal cancer is still controversial. In order to clarify the effect of E-cadherin on the prognosis and clinic......

JIF:3.364

Smart PROTACs Enable Controllable Protein Degradation for Precision Cancer Therapy

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2022; 26 (3)

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional chemicals that degrade proteins at the post-translational level, which represent an em......

JIF:3.364

Development and Evaluation of a Droplet Digital PCR Assay for 8p23 beta-Defensin Cluster Copy Number Determination

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2021; 25 (5)

Introduction It has been proposed that the copy number (CN) variation (CNV) in beta-defensin genes (DEFB) on human chromosome 8p23 determines phenotyp......

Detecting ALK Rearrangement with RT-PCR: A Reliable Approach Compared with Next-Generation Sequencing in Patients with NSCLC

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2021; 25 (4)

Background Precise detection of anaplastic lymphoma kinase (ALK) rearrangement guides the application of ALK-targeted tyrosine kinase inhibitors (ALK-......

BACs-on-Beads Assay for the Prenatal Diagnosis of Microdeletion and Microduplication Syndromes

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2021; 25 (3)

Objective To evaluate the clinical value of BACs-on-Beads (BoBs) assay in detection of microdeletion and microduplication syndromes. Methods A total o......

The Diagnostic Accuracy of miR-371a-3p for Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2021; 25 (3)

Objective This study sought to assess the utility of miR-371a-3p levels as a tool for diagnosing testicular germ cell tumors. Methods For this systema......

The Ubiquitin Proteasome System and Skin Fibrosis

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2021; 25 (1)

The ubiquitin proteasome system (UPS) is a highly conserved way to regulate protein turnover in cells. The UPS hydrolyzes and destroys variant or misf......

High-Speed Quenching Probe-Polymerase Chain Reaction Assay for the Rapid Detection of Carbapenemase-Producing Gene Using GENECUBE: A Fully Automatic Gene Analyzer

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2021; 25 (2)

Background The prevalence of carbapenemase-producing organisms (CPOs) globally poses a public health threat; however, detecting carbapenemases is a ch......

Chromosomal Microarray Analysis for the Fetuses with Aortic Arch Abnormalities and Normal Karyotype

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2020; 24 (5)

Background Aortic arch abnormalities (AAA) are abnormal embryologic developments of the aorta and its branches. Their outcomes often depend on their a......

Preliminary Analysis of B- and T-Cell Responses to SARS-CoV-2

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2020; 24 (5)

Background and Objective Without a specific antiviral treatment or vaccine, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a ......

Discrepancies in Genetic Testing Procedures ofBRCA1/2Mutations: A National Survey Across China

期刊: MOLECULAR DIAGNOSIS & THERAPY, 2020; 24 (6)

International guidelines recommendBRCAtesting for patients with breast and ovarian cancer. Little is known about the genetic testing practices ofBRCA1......

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