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Role of Adaptive Immune and Impacts of Risk Factors on Adaptive Immune in Alzheimer's Disease: Are Immunotherapies Effective or Off-Target?

期刊: NEUROSCIENTIST, ; ()

The pathogenesis of Alzheimer's disease (AD) is complex. Still it remains unclear, which resulted in all efforts for AD treatments with targeting the ......

Neuroinflammation in Parkinson's Disease: Triggers, Mechanisms, and Immunotherapies

期刊: NEUROSCIENTIST, ; ()

Parkinson's disease (PD) is a heterogeneous neurodegenerative disease involving multiple etiologies and pathogenesis, in which neuroinflammation is a ......

Synaptotagmins: Beyond Presynaptic Neurotransmitter Release

期刊: NEUROSCIENTIST, 2020; 26 (1)

Synaptotagmins (Syts) are well-established primary Ca2+ sensors to initiate presynaptic neurotransmitter release. They also play critical roles in the......

Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration

期刊: NEUROSCIENTIST, 2019; 25 (2)

The hippocampus has a critical role in cognition and human memory and is one of the most studied structures in the brain. Despite more than 400 years ......

JIF:6.79

Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative Disorders

期刊: NEUROSCIENTIST, 2019; 25 (6)

Neurodegenerative diseases (NDs) are considered heterogeneous disorders characterized by progressive pathological changes in neuronal systems. Transcr......

JIF:6.79

Spinal Cord Injury: Lessons about Neuroplasticity from Paired Associative Stimulation

期刊: NEUROSCIENTIST, 0; ()

Paired associative stimulation (PAS) is a noninvasive neuromodulation method with rare cases of adverse effects for the patients with neurological inj......

The Expanding Clinical Universe of Polyglutamine Disease

期刊: NEUROSCIENTIST, 2019; 25 (5)

Polyglutamine (polyQ) diseases are a group of hereditary neurodegenerative disorders caused by expansion of unstable polyQ repeats in their associated......

JIF:6.79

Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System

期刊: NEUROSCIENTIST, 2018; 24 (3)

The polycomb repressive complex 2 (PRC2) is responsible for catalyzing both di- and trimethylation of histone H3 at lysine 27 (H3K27me2/3). The subuni......

JIF:6.79

Tinnitus: Prospects for Pharmacological Interventions With a Seesaw Model

期刊: NEUROSCIENTIST, 2018; 24 (4)

Chronic tinnitus, the perception of lifelong constant ringing in ear, is one capital cause of disability in modern society. It is often present with v......

JIF:6.79

Behavioral Manipulation by Optogenetics in the Nonhuman Primate

期刊: NEUROSCIENTIST, 2018; 24 (5)

Given their neuroanatomical similarities to humans and their ability to perform complex behaviors, the nonhuman primate has been an important model fo......

JIF:6.79

Neuroinflammation in Parkinson's Disease: Triggers, Mechanisms, and Immunotherapies

期刊: NEUROSCIENTIST, 2022; 28 (4)

Parkinson's disease (PD) is a heterogeneous neurodegenerative disease involving multiple etiologies and pathogenesis, in which neuroinflammation is a ......

JIF:5.348

Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective

期刊: NEUROSCIENTIST, 2022; 28 (5)

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are activated by glutamate in the central nervous system (CNS). Basical......

JIF:5.348

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