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Analysis based on Monte Carlo simulation: How effective is tigecycline in routine antimicrobial therapy?

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (7)

Objective: This paper aims to assess the efficacy of tigecycline in the treatment of several different infections from a pharmacokinctic/phannacodynam......

Bioequivalence of daclatasvir hydrochloride tablets in healthy Chinese subjects

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (8)

Objective: The aim of the present study was to evaluate the bioequivalence and safety of two types of daclatasvir hydrochloride tablets administered t......

Lopinavir-ritonavir alone or combined with arbidol in the treatment of 73 hospitalized patients with COVID-19: A pilot retrospective study

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (5)

Objectives: This study aimed to evaluate the antiviral efficacy of lopinavir-ritonavir alone or combined with arbidol in the treatment of hospitalized......

Importance of NUDT15 c.415C>T phenotype in treatment of inflammatory bowel disease with azathioprine and occurrence of severe myelosuppression: A case report

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (7)

Azathioprine is one of the main drugs in the treatment of inflammatory bowel disease (IBD). It has been widely used in the remission and maintenance t......

Duodenal perforation caused by imatinib mesylate during adjuvant treatment of gastric stromal tumor: Case report

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (6)

Imatinib, a tyrosine kinase inhibitor, is frequently used to treat unresectable or metastatic gastrointestinal stromal tumors. The application of this......

Evaluation of bioequivalence between generic and brand-name clozapine in Chinese schizophrenic patients: A randomized, two-period, crossover study

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (8)

Objective: Clozapine is the most effective therapy for schizophrenia. This study compared the bioequivalence of a generic formulation of clozapine (Ch......

Chills, fatigue, chest distress, and an abnormal increase in WBC, neutrophil, CRP, and PCT induced by terconazole: A case report

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (7)

The vaginal routes of administration of terconazole, a synthetic triazole derivative, is widely used by patients with uncomplicated vulvovaginal candi......

The successful treatment of 5-fluorouracil overdose caused by the combination of capecitabine and S-1 in an elderly patient

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (3)

Background: 5-fluorouracil (5-FU) is a cytotoxic antimetabolite that interferes with nucleic acid metabolism in both normal and cancer cells. Capecita......

Association of long-term inhalation of caffeine-sodium benzoate with coronary heart disease in men

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (3)

Objective: A possible correlation between caffeine and coronary heart disease (CHD) is controversial. The objective of this study was to explore the e......

Docetaxel exposure and hematological toxicity in Chinese patients with locally advanced/metastatic nasopharyngeal carcinoma

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (3)

Objective: This study aimed to describe the area under the plasma concentration-time curve (AUC) and the relationship with hematological toxicity plus......

Drug therapy strategies for COVID-19 infection during pregnancy

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (3)

Acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread rapidly in numerous countries and caused a massive number of deaths. Interferon-a (IF......

Suppressive effect of vitamin K2 against mitogen-activated peripheral blood mononuclear cells of rheumatoid arthritis patients

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (1)

Objective: To investigate the immunosuppressive effect of vitamin K2 against mitogen-activated peripheral blood mononuclear cells (PBMCs) of rheumatoi......

Evaluation of tofacitinib citrate bioequivalence based on pharmacokinetic parameters in healthy Chinese subjects

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (4)

Objective: To evaluate the pharmacokinetics and bioequivalence of to-facitinib citrate using pharmacokinetic parameters, a single-dose, randomized-seq......

A UPLC-MS/MS method for simultaneous quantification of sildenafil and N-desmethyl sildenafil applied in pharmacokinetic and bioequivalence studies in a Chinese population

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (2)

Objective: To evaluate the pharmacokinetic parameters and bioequivalence of two sildenafil tablets (20 mg) in healthy Chinese subjects. Materials and ......

Antithyroid arthritis syndrome: A case report and review of the literature

期刊: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2021; 59 (2)

A 29-year-old woman was diagnosed with Graves' disease because of her symptoms of thyrotoxicosis. After a 15-day treatment with methimazole, she began......

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