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Comparison of the clinical features and therapeutics of COVID-19 in cardio-cerebrovascular disease (CCVD) and non-CCVD patients

期刊: FRONTIERS OF MEDICINE, 2021; 15 (4)

Cardio-cerebrovascular disease (CCVD) is a major comorbidity of Coronavirus disease 2019 (COVID-19). However, the clinical characteristics and outcome......

Mechanism of insulin resistance in obesity: a role of ATP

期刊: FRONTIERS OF MEDICINE, 2021; 15 (3)

Obesity increases the risk of type 2 diabetes through the induction of insulin resistance. The mechanism of insulin resistance has been extensively in......

Clinical applications of neurolinguistics in neurosurgery

期刊: FRONTIERS OF MEDICINE, 2021; 15 (4)

The protection of language function is one of the major challenges of brain surgery. Over the past century, neurosurgeons have attempted to seek the o......

DDB1-and CUL4-associated factor 8 plays a critical role in spermatogenesis

期刊: FRONTIERS OF MEDICINE, 2021; 15 (2)

Cullin-RING E3 ubiquitin ligase (CRL)-4 is a member of the large CRL family in eukaryotes. It plays important roles in a wide range of cellular proces......

H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis

期刊: FRONTIERS OF MEDICINE, 2021; 15 (2)

The medical fungus Hirsutella sinensis has been used as a Chinese folk health supplement because of its immunomodulatory properties. Our previous stud......

Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity

期刊: FRONTIERS OF MEDICINE, 2021; 15 (4)

Psoraleae Fructus (PF) is a well-known traditional herbal medicine in China, and it is widely used for osteoporosis, vitiligo, and other diseases in c......

Identification of COL3A1 variants associated with sporadic thoracic aortic dissection: a case-control study

期刊: FRONTIERS OF MEDICINE, 2021; 15 (3)

Thoracic aortic dissection (TAD) without familial clustering or syndromic features is known as sporadic TAD (STAD). So far, the genetic basis of STAD ......

Advances in tissue state recognition in spinal surgery: a review

期刊: FRONTIERS OF MEDICINE, 2021; 15 (4)

Spinal disease is an important cause of cervical discomfort, low back pain, radiating pain in the limbs, and neurogenic intermittent claudication, and......

Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections

期刊: FRONTIERS OF MEDICINE, 2021; 15 (4)

The coronavirus disease 2019 (COVID-19) has caused global public health and economic crises. Thus, new therapeutic strategies and effective vaccines a......

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

期刊: FRONTIERS OF MEDICINE, 2021; 15 (3)

Lifestyle interventions, including dietary adjustments and exercise, are important for obesity management. This study enrolled adults with overweight ......

Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic

期刊: FRONTIERS OF MEDICINE, 2021; 15 (4)

The avian influenza A (H7N9) virus is a zoonotic virus that is closely associated with live poultry markets. It has caused infections in humans in Chi......

Intratumor heterogeneity, microenvironment, and mechanisms of drug resistance in glioma recurrence and evolution

期刊: FRONTIERS OF MEDICINE, 2021; 15 (4)

Glioma is the most common lethal tumor of the human brain. The median survival of patients with primary World Health Organization grade IV glioma is o......

Cohort study of patients with Stevens-Johnson syndrome and toxic epidermal necrolysis in China: evaluation of risk models and new predictor of pulmonary consolidation on computed tomography

期刊: FRONTIERS OF MEDICINE, ; ()

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe diseases. This study aimed to validate the predictive ability ......

Targeting "undruggable" c-Myc protein by synthetic lethality

期刊: FRONTIERS OF MEDICINE, ; ()

Synthetic lethal screening, which exploits the combination of mutations that result in cell death, is a promising method for identifying novel drug ta......

Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial

期刊: FRONTIERS OF MEDICINE, ; ()

Tocilizumab has been reported to attenuate the "cytokine storm" in COVID-19 patients. We attempted to verify the effectiveness and safety of tocilizum......

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