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Mechanisms and detection methods of Mycobacterium tuberculosis rifampicin resistance: The phenomenon of drug resistance is complex

期刊: TUBERCULOSIS, 2021; 128 ()

Tuberculosis (TB) is an infectious disease that poses a serious threat to human health. Rifampin (RIF) is an important first-line anti-TB drug, and ri......

Identification of differentially expressed lncRNAs as potential plasma biomarkers for active tuberculosis

期刊: TUBERCULOSIS, 2021; 128 ()

Background: Tuberculosis, one of the deadliest infectious diseases worldwide, is difficult to diagnose. As long noncoding RNAs (lncRNAs) were demonstr......

NF-kappa B-mediated TET2-dependent TNF promoter demethylation drives Mtb-upregulation TNF expression in macrophages

期刊: TUBERCULOSIS, 2021; 129 ()

Tumor necrosis factor (TNF) is essential for the host defense against tuberculosis (TB). However, scarcity or excessive TNF production in macrophages ......

ASAP1 regulates the uptake of Mycobacterium tuberculosis H37Ra in THP1-derived macrophages by remodeling actin cytoskeleton

期刊: TUBERCULOSIS, 2021; 129 ()

Tuberculosis is initiated by the entry of Mycobacterium tuberculosis (Mtb) into macrophages in the lungs. A study of the cellular factors responsible ......

Screening of 20 Mycobacterium tuberculosis sRNAs in plasma for detection of active pulmonary tuberculosis

期刊: TUBERCULOSIS, 2021; 129 ()

Background: Mycobacterium tuberculosis (MTB) sRNAs are abundant. However, the level of MTB sRNA in peripheral blood remains elusive. Methods: Twenty M......

Highly transmitted M. tuberculosis strains are more likely to evolve MDR/XDR and cause outbreaks, but what makes them highly transmitted?

期刊: TUBERCULOSIS, 2021; 129 ()

Multi-Drug-Resistant strains of Mycobacterium tuberculosis (MDR-TB) are a serious obstacle to global TB eradication. While most MDR-TB strains are inf......

Drug resistance, fitness and compensatory mutations in Mycobacterium tuberculosis

期刊: TUBERCULOSIS, 2021; 129 ()

For tuberculosis to be eradicated, the transmission of Multi-Drug-Resistant and eXtensively Drug Resistant strains of Mycobacterium tuberculosis (MDR ......

Genotypic diversity of Mycobacterium tuberculosis isolates and its association with drug-resistance status in Xinjiang, China

期刊: TUBERCULOSIS, 2021; 128 ()

Xinjiang is a unique region of Central Asian part of China. It is widely noted for high tuberculosis burden and particularly for growing prevalence of......

Proteomic analysis reveals critical molecular mechanisms involved in the macrophage anti-spinal tuberculosis process

期刊: TUBERCULOSIS, 2021; 126 ()

Tuberculosis infection activates the autoimmune system. However, the role of host-pathogen interactions involved in Mycobacterium tuberculosis infecti......

Activation of hypoxia-inducible factor 1 (Hif-1) enhanced bactericidal effects of macrophages to Mycobacterium tuberculosis

期刊: TUBERCULOSIS, 2021; 126 ()

Background: Tuberculosis is chronic infection caused by Mycobacterium tuberculosis (M.tb), which infects specifically macrophages. Hif-1, hypoxia-indu......

Mycobacterium tuberculosis strains of the modern Beijing sublineage excessively accumulate triacylglycerols in vitro

期刊: TUBERCULOSIS, 2020; 120 ()

Mycobacterium tuberculosis (Mtb) strains of modern Beijing sublineage appear to be more transmissible and cause more severe disease than strains of ot......

RELL1 inhibits autophagy pathway and regulates Mycobacterium tuberculosis survival in macrophages

期刊: TUBERCULOSIS, 2020; 120 ()

Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb). It leads to approximately 1 million deaths annually. Receptor......

A fieldable electrostatic air sampler enabling tuberculosis detection in bioaerosols

期刊: TUBERCULOSIS, 2020; 120 ()

Tuberculosis (TB) infects about 25% of the world population and claims more human lives than any other infectious disease. TB is spread by inhalation ......

Identification of a novel biomarker based on lymphocyte count, albumin level, and TBAg/PHA ratio for differentiation between active and latent tuberculosis infection in Japan

期刊: TUBERCULOSIS, 2020; 125 ()

Data from China have shown that the ratio of Mycobacterium tuberculosis-specific antigen (TBAg) spots obtained from the T-SPOT.TB test to the number o......

The effect of micro-nutrients on malnutrition, immunity and therapeutic effect in patients with pulmonary tuberculosis: A systematic review and meta-analysis of randomised controlled trials

期刊: TUBERCULOSIS, 2020; 125 ()

Objective: Micro-nutrients are closely related to pulmonary tuberculosis (PTB). Most patients with PTB suffer from micro-nutrients deficiency. We aime......

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