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MiR-452-5p mediates the proliferation, migration and invasion of hepatocellular carcinoma cells via targeting COLEC10

期刊: PERSONALIZED MEDICINE, 2021; 18 (2)

Objective: This study explored the potential function of miR-452-5p in hepatocellular carcinoma (HCC) and clarified the mechanism underlying HCC progr......

Association study of genetic polymorphisms in GABRD with treatment response and dose in methadone maintenance treatment

期刊: PERSONALIZED MEDICINE, 2021; 18 (05)

Aim: This study determined if gene variants in the GABA receptor delta subunit (GABRD) are associated with treatment response and dose in methadone ma......

MiR-455-5p serves as a biomarker of atherosclerosis and inhibits vascular smooth muscle cell proliferation and migration

期刊: PERSONALIZED MEDICINE, 2021; 18 (3)

Background: This study discussed the clinical value and expression level of miR-455-5p in atherosclerosis (AS) patients. Meanwhile, its regulatory eff......

Concentration and integrity indexes of urine cell-free DNA as promising biomarkers for early lung cancer diagnosis

期刊: PERSONALIZED MEDICINE, 2021; 18 (2)

Aim: To explore the role of urine cell-free DNA (ucfDNA) concentration and integrity indexes as potential biomarkers for lung cancer diagnosis. Materi......

Personalized medicine in lipid-modifying therapy

期刊: PERSONALIZED MEDICINE, 2021; 18 (2)

The choice of lipid-modifying treatment is largely based on the absolute level of cardiovascular risk and baseline lipid profile. Statins are the firs......

miR-369-3p serves as prognostic factor and regulates cancer progression of hepatocellular carcinoma

期刊: PERSONALIZED MEDICINE, 2021; 18 (4)

Background: The aim of this study was to investigate the role of miR-369-3p in hepatocellular carcinoma (HCC). Materials & methods: The expression......

Elevated expression of ASF1B correlates with poor prognosis in human lung adenocarcinoma

期刊: PERSONALIZED MEDICINE, 2021; 18 (2)

Aim: ASF1 is involved in tumorigenesis. However, its possible role in lung adenocarcinoma (LUAD) is unclear. This study thus explored the role of ASF1......

Lipoprotein(a) as a marker for predicting coronary collateral circulation in patients with acute myocardial infarction

期刊: PERSONALIZED MEDICINE, 2020; 17 (1)

Aim: The aim of the present study was to examine the predictive value of lipoprotein(a) (Lp[a]) levels for coronary collateral circulation (CCC) in pa......

Dexmedetomidine improves neurodevelopment and cognitive impairment in infants with congenital heart disease

期刊: PERSONALIZED MEDICINE, 2020; 17 (1)

Aim: Explore if dexmedetomidine (DEX) improves neurodevelopment and cognitive impairment in infants with congenital heart disease. Materials & met......

Individualized medication of digoxin based on the serum drug concentration and blood biochemical indexes

期刊: PERSONALIZED MEDICINE, 2020; 17 (1)

Aim: The dose of digoxin is often difficult to be determined precisely. The aim of this study was to retrospectively investigate the effect of blood b......

Association of CYP2C19 and UGT1A4 polymorphisms with voriconazole-induced liver injury

期刊: PERSONALIZED MEDICINE, 2020; 17 (1)

Aim: This study investigated the association between voriconazole-induced liver injury and gene polymorphisms of CYP2C19 and UGT1A4. Materials & m......

Rs739837 affects the severity of asthma by disrupting the binding of microRNA-885

期刊: PERSONALIZED MEDICINE, 2020; 17 (2)

Aim: This study investigated the molecular mechanism underlying the involvement of miR-885 in the signaling pathways of VDR. Results: Based on their r......

Positive association of SCD1 genetic variation and metabolic syndrome in dialysis patients in China

期刊: PERSONALIZED MEDICINE, 2020; 17 (2)

Aim: Metabolic syndrome (MetS) diagnosed in the dialysis patients is increasingly reported which worsens the prognosis of the renal diseases. The rela......

Predictive value of leukocyte telomere length for the severity of coronary artery disease

期刊: PERSONALIZED MEDICINE, 2020; 17 (3)

Aim: This study aimed to explore leukocyte telomere length (LTL) in the prediction of the severity of coronary artery disease (CAD). Materials & m......

Association between functional polymorphisms in the promoter of the miR-143/145 cluster and risk of conotruncal heart defects

期刊: PERSONALIZED MEDICINE, 2019; 16 (6)

Aim: Conotruncal heart defects (CTDs) are the most common form of congenital heart disease. We investigated the association of these two single-nucleo......

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