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The role of the TGF-beta/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Objective: The present study aims to explore the correlation of the transforming growth factor beta (TGF-beta), drosophila mothers against decapentapl......

Systematic study of single-cell isolation from musculoskeletal tissues for single-sell sequencing

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background The single-cell platform provided revolutionary way to study cellular biology. Technologically, a sophistic protocol of isolating qualified......

IDPsBind: a repository of binding sites for intrinsically disordered proteins complexes with known 3D structures

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background: Intrinsically disordered proteins (IDPs) lack a stable three-dimensional structure under physiological conditions but play crucial roles i......

Activated TRPA1 plays a therapeutic role in TMZ resistance in glioblastoma by altering mitochondrial dynamics

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background Glioblastoma (GBM) represents nearly one-half of primary brain tumors, and the median survival of patients with GBM is only 14.6 months. Su......

MAPKAPK5-AS1 drives the progression of hepatocellular carcinoma via regulating miR-429/ZEB1 axis

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background: Hepatocellular carcinoma (HCC) is a common malignancy. Long non-coding RNAs (lncRNAs) partake in the progression of HCC. However, the role......

Effects of growth hormone/estrogen/androgen on COVID-19-type proinflammatory responses in normal human lung epithelial BEAS-2B cells

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background COVID-19 is a disease caused by SARS-CoV-2, which can cause mild to serious infections in humans. We aimed to explore the effect of growth ......

An integrative analysis of DNA methylation and transcriptome showed the dysfunction of MAPK pathway was involved in the damage of human chondrocyte induced by T-2 toxin

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background T-2 toxin is thought to induce the growth plate and articular cartilage damage of Kashin-Beck disease (KBD), an endemic osteochondropathy i......

Decreased Kruppel-like factor 4 in adenomyosis impairs decidualization by repressing autophagy in human endometrial stromal cells

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background Poor decidualization and abnormal autophagy conditions in the endometria of adenomyosis patients have been reported previously. However, th......

Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-beta/SMAD3 signaling pathway

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background: Triple-negative breast cancer (TNBC) is the most severe type of breast cancer owing to its high heterogeneity, aggressiveness and lack of ......

CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Cervical cancer is an important malignant tumor threatening the physical and mental health of women in the world. As a new calcium activated chloride ......

Ribosomal protein RPL5 regulates colon cancer cell proliferation and migration through MAPK/ERK signaling pathway

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background Abnormal expression of ribosomal proteins has an important regulatory effect on the progression of cancer. RPL5 is involved in the progress......

OSGIN2 regulates osteogenesis of jawbone BMSCs in osteoporotic rats

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background Augmentation of oxidative stress after estrogen deficiency leading to functional deficiency of jawbone bone marrow mesenchymal stem cells (......

Metabolic analysis of the regulatory mechanism of sugars on secondary flowering in Magnolia

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background: Magnolia, a traditional and important ornamental plant in urban greening, has been cultivated for about 2000 years in China for its elegan......

Downregulation of miR-451 in cholangiocarcinoma help the diagnsosi and promotes tumor progression

期刊: BMC MOLECULAR AND CELL BIOLOGY, 2022; 23 (1)

Background Cholangiocarcinoma is a kind of invasive malignant tumor followed by hepatocellular carcinoma. miR-451 was suggested to function as regulat......

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