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Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-kappa B signaling pathway

期刊: GENES & GENOMICS, 2021; 43 (8)

Background Glabridin (GB), a bio-available phytoestrogen, displays various biological properties such as anti-inflammatory, antibacterial, and antivir......

Phosphoinositide-specific phospholipase C gene involved in heat and drought tolerance in wheat (Triticum aestivum L.)

期刊: GENES & GENOMICS, 2021; 43 (10)

Background Phosphoinositide-specific phospholipase C proteins mediate environmental stress responses in many plants. However, the potential of PI-PLC ......

Using weighted gene co-expression network analysis (WGCNA) to identify the hub genes related to hypoxic adaptation in yak (Bos grunniens)

期刊: GENES & GENOMICS, 2021; 43 (10)

Background As a mammal living at the highest altitude in the world, the yak has strong adaptability to the harsh natural environment (such as low temp......

Identification of a 193 bp promoter region of TaNRX1-D gene from common wheat that contributes to osmotic or ABA stress inducibility in transgenic Arabidopsis

期刊: GENES & GENOMICS, 2021; 43 (9)

Background Cloning and characterizing the drought-inducible promoters is essential for their use in crop resistance's genetic improvement. Previous st......

LINC00943 knockdown exerts neuroprotective effects in Parkinson's disease through regulates CXCL12 expression by sponging miR-7-5p

期刊: GENES & GENOMICS, 2021; 43 (7)

Background Parkinson's disease (PD) is a common neurodegenerative movement disorder, but the pathogenesis is still unclear. Long non-coding RNAs (lncR......

Long non-coding RNA HOTAIR promotes hepatocellular carcinoma progression by regulating miR-526b-3p/DHX33 axis

期刊: GENES & GENOMICS, 2021; 43 (8)

Background Hepatocellular carcinoma (HCC) is one of the most common human cancers. Long non-coding RNAs (lncRNAs) play pivotal roles in progression of......

Tumor suppressive effect of scavenger receptor class A member 5 overexpression in colorectal cancer by regulating PI3K/AKT/mTOR pathway

期刊: GENES & GENOMICS, 2021; 43 (10)

Background Colorectal cancer (CRC) exhibits high risks of morbidity and mortality. Objective To investigate the effect of scavenger receptor class A m......

Baicalin attenuates adriamycin-induced nephrotic syndrome by regulating fibrosis procession and inflammatory reaction

期刊: GENES & GENOMICS, 2021; 43 (9)

Background Baicalin has anti-inflammatory, antibacterial, blood platelet aggregation-inhibiting, free oxygen radical-clearing, and endotoxin-decreasin......

MiR-137 inhibits the proliferation, invasion and migration of glioma via targeting to regulate EZH2

期刊: GENES & GENOMICS, 2021; 43 (10)

Background Gliomas are common malignant tumors in the nervous system, known for poor prognosis and low survival rate. Objective This study aims to exp......

Propofol enhanced the cell sensitivity to paclitaxel (PTX) in prostatic cancer (PC) through modulation of HOTAIR

期刊: GENES & GENOMICS, 2021; 43 (7)

Background PTX is widely used in cancer treatments. Objective In this paper, we explored the role and potential molecular mechanism of propofol in reg......

Genome-wide association analysis for yield-related traits at the R6 stage in a Chinese soybean mini core collection

期刊: GENES & GENOMICS, 2021; 43 (8)

Background Soybean (Glycinemax (L.) Merr.) is an economically important crop for vegetable oil and protein production, and yield is a critical trait f......

A comprehensive analysis of gorilla-specific LINE-1 retrotransposons

期刊: GENES & GENOMICS, 2021; 43 (10)

Background Long interspersed element-1 (LINE-1 or L1) is the most abundant retrotransposons in the primate genome. They have approximately 520,000 cop......

Disheveled-associated activator of morphogenesis 2 promotes invasion of colorectal cancer by activating PAK1 and promoting MMP7 expression

期刊: GENES & GENOMICS, 2021; 43 (8)

Background Disheveled-associated activator of morphogenesis (DAAM) family, including DAAM1 and DAAM2, is key regulators in Wnt signaling pathway. Alth......

MicroRNA-9 inhibits proliferation and progression in retinoblastoma cells by targeting PTEN

期刊: GENES & GENOMICS, 2021; 43 (9)

Background Retinoblastoma (RB) is the most prevalent primary intraocular malignancy, which commonly occurs during infant and childhood. Objective Our ......

GAS5 regulates viability and apoptosis in TGF-beta 1-stimulated bronchial epithelial cells by regulating miR-217/HDAC4 axis

期刊: GENES & GENOMICS, 2021; 43 (8)

Background Asthma is a serious respiratory disease that affects the physical and mental health of children. Airway epithelial apoptosis concomitantly ......

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