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Upregulated lnc-HZ02 and miR-hz02 inhibited migration and invasion by downregulating the FAK/SRC/PI3K/AKT pathway in BPDE-treated trophoblast cells

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (6)

BPDE (benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide), a metabolite of environmental carcinogenic BaP, weakens the migration and invasion of human villous......

Cirsilineol attenuates LPS-induced inflammation in both in vivo and in vitro models via inhibiting TLR-4/NF kB/IKK signaling pathway

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (8)

The anti-inflammatory activity of cirsilineol in in vivo condition was assessed by measuring the relative organ weight, lung dry/wet weight ratio, pro......

Estradiol exerts a neuroprotective effect on SH-SY5Y cells through the miR-106b-5p/TXNIP axis

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (9)

Alzheimer's disease (AD) is a neurodegenerative disease. Thioredoxin and thioredoxin-interacting protein (TXNIP) complexes help sustain cell oxidation......

Biochemical and cytotoxic evaluation of latroeggtoxin-VI against PC12 cells

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (8)

Latroeggtoxin-VI (LETX-VI) is a peptide neurotoxin discovered from Latrodectus tredecimguttatus eggs. In the current study, the action features of the......

Exaggerated activities of TRPM7 underlie bupivacaine-induced neurotoxicity in the SH-SY5Y cells preconditioned with high glucose

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (8)

Hyperglycemia is considered a risk factor for the enhancement of local anesthetic-induced neurotoxicity. Transient receptor potential melastatin 7 (TR......

Rutin restrains the growth and metastasis of mouse breast cancer cells by regulating the microRNA-129-1-3p-mediated calcium signaling pathway

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (7)

Breast cancer is a common malignancy that is highly lethal. Due to the poor prognosis, more effective and efficient treatment methods are urgently nee......

Pseudogene ANXA2P2 knockdown shows tumor-suppressive function by inhibition of the PI3K/PKB pathway in glioblastoma cells

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (8)

The pseudogene annexin A2 pseudogene 2 (ANXA2P2) is highly expressed in glioblastoma (GBM). However, its role and mechanism involved in the progressio......

Cr(VI)-induced DNA damage is lessened by the modulation of hsp70 via increased GSH de novo synthesis in Drosophila melanogaster

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (8)

Hexavalent chromium [Cr(VI)] is a genotoxic chemical, and in the chemical-exposed organism, oxidative stress is one of the leading causative mechanism......

Hesperidin alleviates bupivacaine anesthesia-induced neurotoxicity in SH-SY5Y cells by regulating apoptosis and oxidative damage

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (7)

Local anesthetic with bupivacaine (BV) administration may cause severe neurotoxicity and neurological complications in developing neurons. Any substan......

beta-Asarone suppresses TNF-alpha expression through DNA methylation and c-Jun-mediated transcription modulation in scratch-injured neuronal cells

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (7)

This study aimed to investigate the role and possible mechanism of beta-asarone in regulating neuronal apoptosis and axonal regeneration. A scratch in......

Vorinostat ameliorates IL-1 alpha-induced reduction of type II collagen by inhibiting the expression of ELF3 in chondrocytes

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (9)

Osteoarthritis (OA) is a common joint disease that ultimately causes physical disability and imposes an economic burden on society. Cartilage destruct......

TMEM88 exhibits an antiproliferative and anti-invasive effect in bladder cancer by downregulating Wnt/beta-catenin signaling

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (8)

Transmembrane protein 88 (TMEM88) acts as a novel tumor-associated protein. The dysregulation of TMEM88 has been observed in several tumor types. Howe......

Protective effect of rhaponticin on ovariectomy-induced osteoporosis in rats

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (9)

Rhaponticin is a constituent isolated from numerous medicinal herbs. It has been reported earlier that rhaponticin possesses numerous biological effec......

Faster lipid beta-oxidation rate by acetyl-CoA carboxylase 2 inhibition alleviates high-glucose-induced insulin resistance via SIRT1/PGC-1 alpha in human podocytes

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (7)

Diabetic nephropathy (DN) is becoming a research hotspot in recent years because the prevalence is high and the prognosis is poor. Lipid accumulation ......

Antiosteoporotic effect of hesperidin against ovariectomy-induced osteoporosis in rats via reduction of oxidative stress and inflammation

期刊: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021; 35 (8)

Osteoporosis is a serious health problem, especially in geriatric patients. Worldwide, it affects 8.9 million people every year. Oxidative stress and ......

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