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Voluntary wheel running is capable of improving cognitive function only in the young but not the middle-aged male APPSwe/PS1De9 mice

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 145 ()

To determine whether voluntary wheel running could improve cognitive function from both the young and middle-aged APP/PS1 mice and the underlying mech......

A novel method for detecting heteromeric complexes at synaptic level by combining a modified method of proximity ligation assay with transmission electron microscopy

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 149 ()

The heteromeric complexes of adenosine 2A receptor (A2AR) and N-methyl-D-aspartate receptor (NMDAR) have recently been confirmed in cell experiments, ......

Potential of extracellular vesicles in the Parkinson's disease-Pathological mediators and biomarkers

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 144 ()

Parkinson?s disease (PD) is an age-related neurodegenerative disorder characterized by the progressive deterioration of motor function. Histopathologi......

HAGLR aggravates neuropathic pain and promotes inflammatory response and apoptosis of lipopolysaccharide-treated SH-SY5Y cells by sequestering miR-182-5p from ATAT1 and activating NLRP3 inflammasome

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 145 ()

Background: Chronic neuropathic pain is characterized by neuroinflammation. Previously, long noncoding RNA (lncRNA) HAGLR was reported to regulate the......

Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 148 ()

Objective: Chemokines regulate infiltration of immune cells to brain in inflammation. Cathepsin C (CatC), a lysosomal protease, has been found to part......

The role of lncRNAs in ischemic stroke

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 147 ()

Ischemic stroke is a leading cause of disability and mortality worldwide due to the narrow therapeutic time window of the only two approved therapies,......

Succinate accumulation contributes to oxidative stress and iron accumulation in pentylenetetrazol-induced epileptogenesis and kainic acid-induced seizure

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 149 ()

This study explored the role of succinate accumulation in the oxidative stress and iron accumulation in both pentylenetetrazol (PTZ)-induced epileptog......

17 beta-oestradiol alleviates endoplasmic reticulum stress injury induced by chronic cerebral hypoperfusion through the Haemoglobin/HIF 1 alpha signalling pathway in ovariectomized rats

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 148 ()

Endoplasmic reticulum stress (ERS) is known to be an essential target in protecting against ischaemic brain injury. In this study, using a vascular de......

Long non-coding RNA: An underlying bridge linking neuroinflammation and central nervous system diseases

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 148 ()

Central nervous system (CNS) diseases are responsible for a large proportion of morbidity and mortality worldwide. CNS diseases caused by intrinsic an......

Pramipexole attenuates neuronal injury in Parkinson's disease by targeting miR-96 to activate BNIP3-mediated mitophagy

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 146 ()

Background: Parkinson?s disease is a common neurodegenerative problem. Pramipexole (PPX) plays protective role in Parkinson?s disease. Nevertheless, t......

Activated microglia facilitate the transmission of alpha-synuclein in Parkinson's disease

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 148 ()

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and abnormal aggregates of alpha-s......

Regulation of blood-brain barrier permeability by Salvinorin A via alleviating endoplasmic reticulum stress in brain endothelial cell after ischemia stroke

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 149 ()

Inhibition of endoplasmic reticulum (ER) stress reduces blood-brain barrier (BBB) injury caused by ischemia/ reperfusion (I/R), with indistinct mechan......

Role of the endolysosomal pathway and exosome release in tau propagation

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 145 ()

The progressive deposition of misfolded and aggregated forms of Tau protein in the brain is a pathological hallmark of tauopathies, such as Alzheimer?......

Down-regulation of astrocytic sonic hedgehog by activation of endothelin ETB receptors: Involvement in traumatic brain injury-induced disruption of blood brain barrier in a mouse model

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 146 ()

In the adult brain, sonic hedgehog acts on cerebral microvascular endothelial cells to stabilize the blood-brain barrier. The expression of sonic hedg......

Phragmunis a suppresses glioblastoma through the regulation of MCL1-FBXW7 by blocking ELK1-SRF complex-dependent transcription

期刊: NEUROCHEMISTRY INTERNATIONAL, 2021; 147 ()

Glioblastoma (GBM) is a highly aggressive brain tumor. During screening work, we found a new compound named phragmunis A (PGA), which is derived from ......

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