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Zebrafish as a Model for In-Depth Mechanistic Study for Stroke

期刊: TRANSLATIONAL STROKE RESEARCH, 2021; 12 (5)

Stroke is one of the world's leading causes of death and disability, posing enormous burden to the society. However, the pathogenesis and mechanisms t......

Carbonyl Reductase 1 Attenuates Ischemic Brain Injury by Reducing Oxidative Stress and Neuroinflammation

期刊: TRANSLATIONAL STROKE RESEARCH, 2021; 12 (5)

Oxidative stress and neuroinflammatory response after the ischemic injury are important pathophysiologic mechanisms that cause brain tissue loss and n......

Inhibition of Dectin-1 Ameliorates Neuroinflammation by Regulating Microglia/Macrophage Phenotype After Intracerebral Hemorrhage in Mice

期刊: TRANSLATIONAL STROKE RESEARCH, ; ()

Polarization of microglia/macrophages toward the pro-inflammatory phenotype is an important contributor to neuroinflammation after intracerebral hemor......

Neurovascular Units and Neural-Glia Networks in Intracerebral Hemorrhage: from Mechanisms to Translation

期刊: TRANSLATIONAL STROKE RESEARCH, ; ()

Intracerebral hemorrhage (ICH), the most lethal type of stroke, often leads to poor outcomes in the clinic. Due to the complex mechanisms and cell-cel......

Ifenprodil Improves Long-Term Neurologic Deficits Through Antagonizing Glutamate-Induced Excitotoxicity After Experimental Subarachnoid Hemorrhage

期刊: TRANSLATIONAL STROKE RESEARCH, ; ()

Excessive glutamate leading to excitotoxicity worsens brain damage after SAH and contributes to long-term neurological deficits. The drug ifenprodil i......

Increased Renal Dysfunction, Apoptosis, and Fibrogenesis Through Sympathetic Hyperactivity After Focal Cerebral Infarction

期刊: TRANSLATIONAL STROKE RESEARCH, ; ()

Sympathetic nervous system plays an important role in secondary injury of diseases. Accumulating evidence has observed association between ischemic st......

Mechanical Thrombectomy in Nonagenarians: a Systematic Review and Meta-analysis

期刊: TRANSLATIONAL STROKE RESEARCH, ; ()

This systematic review and meta-analysis aimed to summarize the current literature on mechanical thrombectomy (MT) in nonagenarians and to provide upd......

The Key Regulator of Necroptosis, RIP1 Kinase, Contributes to the Formation of Astrogliosis and Glial Scar in Ischemic Stroke

期刊: TRANSLATIONAL STROKE RESEARCH, ; ()

Necroptosis initiation relies on the receptor-interacting protein 1 kinase (RIP1K). We recently reported that genetic and pharmacological inhibition o......

White Matter Free Water is a Composite Marker of Cerebral Small Vessel Degeneration

期刊: TRANSLATIONAL STROKE RESEARCH, ; ()

To investigate the association between white matter free water (FW) and common imaging markers of cerebral small vessel diseases (CSVD) in two groups ......

Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit

期刊: TRANSLATIONAL STROKE RESEARCH, 2020; 11 (4)

The homeostasis of the neurovascular unit (NVU) is disrupted after traumatic brain injury (TBI), and therapeutic strategies targeting the NVU would li......

Recombinant Adiponectin Peptide Ameliorates Brain Injury Following Intracerebral Hemorrhage by Suppressing Astrocyte-Derived Inflammation via the Inhibition of Drp1-Mediated Mitochondrial Fission

期刊: TRANSLATIONAL STROKE RESEARCH, 2020; 11 (5)

Intracerebral hemorrhage (ICH) is a life-threatening subtype of cerebral stroke with high morbidity and mortality; however, effective treatment for IC......

Silencing of Long Non-coding RNA GAS5 Suppresses Neuron Cell Apoptosis and Nerve Injury in Ischemic Stroke Through Inhibiting DNMT3B-Dependent MAP4K4 Methylation

期刊: TRANSLATIONAL STROKE RESEARCH, 2020; 11 (5)

Ischemic stroke is associated with various physiological and pathological processes including neuronal apoptosis. Growth-arrest-specific transcript 5 ......

FasL-PDPK1 Pathway Promotes the Cytotoxicity of CD8(+) T Cells During Ischemic Stroke

期刊: TRANSLATIONAL STROKE RESEARCH, 2020; 11 (4)

CD8(+) T cells are recognized as key players in exacerbation of ischemic stroke; however, the underlying mechanism in modulating the function of CD8(+......

Low Hemoglobin Levels at Admission Are Independently Associated with Cognitive Impairment after Ischemic Stroke: a Multicenter, Population-Based Study

期刊: TRANSLATIONAL STROKE RESEARCH, 2020; 11 (5)

Data on the association between hemoglobin (Hb) levels and poststroke cognitive function are limited. We investigated the relationship between Hb conc......

PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice

期刊: TRANSLATIONAL STROKE RESEARCH, 2020; 11 (5)

Postsynaptic density protein-93 (PSD-93) plays an important role in ischemic brain injury through N-methyl-d-aspartate receptor (NMDAR)-triggered neur......

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