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Plasma extracellular vesicle delivery of miR-210-3p by targeting ATG7 to promote sepsis-induced acute lung injury by regulating autophagy and activating inflammation

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (7)

Extracellular vesicles (EVs) can be used for intercellular communication by facilitating the transfer of miRNAs from one cell to a recipient cell. Mic......

Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (4)

Senile osteoporosis can cause bone fragility and increased fracture risks and has been one of the most prevalent and severe diseases affecting the eld......

MD2 blockade prevents modified LDL-induced retinal injury in diabetes by suppressing NADPH oxidase-4 interaction with Toll-like receptor-4

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (4)

Modified LDL-induced inflammation and oxidative stress are involved in the pathogenesis of diabetic retinopathy. Recent studies have also shown that m......

miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/beta-catenin signaling pathway

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (5)

Bone marrow mesenchymal stem cell (BMSC)-derived exosomes have been found to enhance fracture healing. In addition, microRNAs contributing to the heal......

Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (4)

Bone degeneration: Identifying a damage-limiting protein The protein optineurin is implicated in regulating the breakdown of bone during natural maint......

RBM24 exacerbates bladder cancer progression by forming a Runx1t1/TCF4/miR-625-5p feedback loop

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (5)

RNA-binding motif protein 24 (RBM24) acts as a multifunctional determinant of cell fate, proliferation, apoptosis, and differentiation during developm......

Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (4)

The adult pancreatic ductal system was suggested to harbor facultative beta-cell progenitors similar to the embryonic pancreas, and the appearance of ......

Aurora kinase A, a synthetic lethal target for precision cancer medicine

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (5)

Recent advances in high-throughput sequencing technologies and data science have facilitated the development of precision medicine to treat cancer pat......

Sublytic C5b-9 induces glomerular mesangial cell proliferation via ERK1/2-dependent SOX9 phosphorylation and acetylation by enhancing Cyclin D1 in rat Thy-1 nephritis

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (4)

Glomerular mesangial cell (GMC) proliferation is a histopathological alteration in human mesangioproliferative glomerulonephritis (MsPGN) or in animal......

Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (5)

Ulcerative colitis (UC) is a chronic recurrent intestinal inflammatory disease characterized by high incidence and young onset age. Recently, there ha......

Mitochondrial quality control in intervertebral disc degeneration

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (7)

Intervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the human lifespan that can increase the risk of low back pain. Mor......

Biological importance of OCT transcription factors in reprogramming and development

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (6)

Ectopic expression of Oct4, Sox2, Klf4 and c-Myc can reprogram somatic cells into induced pluripotent stem cells (iPSCs). Attempts to identify genes o......

WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (6)

Ongoing chronic fibrosis and hypertrophy of the ligamentum flavum (LF) is an important cause of lumbar spinal canal stenosis (LSCS). Our previous work......

PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, 2021; 53 (5)

Osteoporosis: An RNA molecule that suppresses bone-building A recently identified regulatory RNA molecule contributes to osteoporosis by suppressing p......

Splenectomy improves liver fibrosis via tumor necrosis factor superfamily 14 (LIGHT) through the JNK/TGF-beta 1 signaling pathway

期刊: EXPERIMENTAL AND MOLECULAR MEDICINE, ; ()

Splenectomy has been reported to improve liver fibrosis in patients with cirrhosis and hypersplenism. However, the mechanisms remain unclear. Tumor ne......

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