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Contribution of FBLN5 to Unstable Plaques in Carotid Atherosclerosis via mir128 and mir532-3p Based on Bioinformatics Prediction and Validation

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

FBLN5, a member of the short fibulins in the fibulin family of extracellular matrix/matricellular proteins, is involved in interactions with component......

miR-145-5p Inhibits Neuroendocrine Differentiation and Tumor Growth by Regulating the SOX11/MYCN Axis in Prostate cancer

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Recent studies have shown that the downregulation of miR-145-5p in prostate cancer (PCa) is significantly associated with poor differentiation and pro......

Profile and Functional Prediction of Plasma Exosome-Derived CircRNAs From Acute Ischemic Stroke Patients

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Stroke is one of the major causes of death and long-term disability, of which acute ischemic stroke (AIS) is the most common type. Although circular R......

Genome-Wide Identification and Functional Characterization of the Chloride Channel TaCLC Gene Family in Wheat (Triticum aestivum L.)

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

In plants, chloride channels (CLC) are involved in a series of specific functions, such as regulation of nutrient transport and stress tolerance. Memb......

Use of miRNA Sequencing to Reveal Hub miRNAs and the Effect of miR-582-3p/SMAD2 in the Progression of Hepatocellular Carcinoma

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Hepatocellular carcinoma is a common tumor with a high fatality rate worldwide, and exploring its pathogenesis and deterioration mechanism is a focus ......

Co-Expression Network Modeling Identifies Specific Inflammation and Neurological Disease-Related Genes mRNA Modules in Mood Disorder

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Objectives: Mood disorders are a kind of serious mental illness, although their molecular factors involved in the pathophysiology remain unknown. One ......

Construction of a Novel Immune-Related mRNA Signature to Predict the Prognosis and Immune Characteristics of Human Colorectal Cancer

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Background: Anti-cancer immunotherapeutic approaches have gained significant efficacy in multiple cancer types. However, not all patients with colorec......

Clinical and Genetic Characteristics of IKZF1 Mutation in Chinese Children With B-Cell Acute Lymphoblastic Leukemia

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Acute lymphoblastic leukemia (ALL) is a malignancy associated with altered lymphoid precursor hyperplasia and accompanied with different genetic mutat......

XGEM: Predicting Essential miRNAs by the Ensembles of Various Sequence-Based Classifiers With XGBoost Algorithm

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

MicroRNAs (miRNAs) play vital roles in gene expression regulations. Identification of essential miRNAs is of fundamental importance in understanding t......

MiR-372-3p Functions as a Tumor Suppressor in Colon Cancer by Targeting MAP3K2

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

MicroRNAs (miRNAs) as small non-coding RNA transcripts bind their complementary sequences in the 3 '-untranslated region (3 '-UTR) of target messenger......

Construction of the Six-lncRNA Prognosis Signature as a Novel Biomarker in Esophageal Squamous Cell Carcinoma

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Esophageal squamous cell carcinoma (ESCC) is a common malignant gastrointestinal tumor threatening global human health. For patients diagnosed with ES......

Genetic Variants of Glycogen Metabolism Genes Were Associated With Liver PDFF Without Increasing NAFLD Risk

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Background/Aims: The storage amount of liver glycogen could affect the liver fibrosis assessment made by MRI-based methods. However, it remained uncle......

Fluvalinate-Induced Changes in MicroRNA Expression Profile of Apis mellifera ligustica Brain Tissue

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Fluvalinate is a widely used and relatively safe acaricide for honeybees, but it still has a negative impact on honeybee colonies. Such negative effec......

PHDMF: A Flexible and Scalable Personal Health Data Management Framework Based on Blockchain Technology

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Currently, most of the personal health data (PHD) are managed and stored separately by individual medical institutions. When these data need to be sha......

Prognostic Value and Therapeutic Perspectives of CXCR Members in the Glioma Microenvironment

期刊: FRONTIERS IN GENETICS, 2022; 13 ()

Background: CXCR (CXC Chemokine Receptor) is a complex of the immune-associated protein involved in tumor activation, invasion, migration, and angioge......

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