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Gene-Gene Interactions of Gemcitabine Metabolizing-Enzyme Genes hCNT3 and WEE1 for Preventing Severe Gemcitabine-Induced Hematological Toxicity

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 61 (10)

Most patients experience severe hematological toxicity during treatment with gemcitabine; thus, preventing such toxicity would improve the treatment e......

Further Evaluation of Coproporphyrins as Clinical Endogenous Markers for OATP1B

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 61 (8)

Coproporphyrins (CP-I and CP-III) in plasma are considered potential markers for assessing liver organic anion-transporting polypeptide transporter OA......

Population Pharmacokinetic Analysis of Recombinant Factor VIII Fc Fusion Protein in Subjects With Severe Hemophilia A: Expanded to Include Pediatric Subjects

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 61 (7)

Recombinant factor VIII Fc fusion protein (rFVIIIFc) has been indicated for adults and children with hemophilia A. The objective of this article was t......

Exploring the Relationship Between Colorectal Cancer and Allopurinol: A Taiwanese Population-Based Propensity-Matched Case-Control Study

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, ; ()

The role of allopurinol usage in colorectal cancer (CRC) has no definite conclusion. The aim of this study was to explore the correlation between allo......

Overview on the Amendments of Provisions for Drug Registration in China

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 61 (1)

The revised Provisions for Drug Registration was promulgated by the State Administration for Market Regulation of China in March 2020 and came into fo......

Endocrine Adverse Events Caused by Different Types and Different Doses of Immune Checkpoint Inhibitors in the Treatment of Solid Tumors: A Meta-Analysis and Systematic Review

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2021; 61 (3)

The aim of this meta-analysis was to assess the risks of endocrine adverse events in patients with malignancies treated with different types and diffe......

Comparison of the Effects of Low-Molecular-Weight Heparin and Fondaparinux on Liver Function in Patients With Pulmonary Embolism

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 60 (12)

Hepatotoxicity with low-molecular-weight heparin (LMWH) or fondaparinux is a relatively common adverse reaction. This study assessed the effects of LM......

Proton Pump Inhibitor Use Before ICU Admission Is Not Associated With Mortality of Critically Ill Patients

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 60 (7)

Some studies have shown that the long-term use of proton pump inhibitors (PPIs) is associated with many adverse events that may increase mortality; ho......

Development of a Physiologically Based Pharmacokinetic Model for Prediction of Pramipexole Pharmacokinetics in Parkinson's Disease Patients With Renal Impairment

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 60 (8)

Pramipexole is the first-line medication recommended by the British National Institute for Health and Care Excellence. Pramipexole is predominantly el......

Effects of Atypical Antipsychotics on Neuroactive Vitamins in Patients With Schizophrenia

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 60 (10)

In schizophrenia, neuroactive vitamins A/D/E play vital neuroprotective roles in its pathophysiological processes. During medical treatment, atypical ......

Population Pharmacokinetics and Pharmacodynamics of Norvancomycin in Children With Malignant Hematological Disease

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2020; 60 (9)

Knowledge of pharmacokinetic (PK) behavior of norvancomycin (NVCM) in pediatric patients is lacking, which leads to empirical therapy in clinical prac......

Rash and Pruritus With PD-1 Inhibitors in Cancer Patients: A Meta-Analysis of Randomized Controlled Trials

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2019; 59 (1)

We performed a systematic review and meta-analysis to fully investigate the rash and pruritus of programmed death-1 (PD-1) inhibitors in cancer patien......

JIF:2.91

Population Pharmacokinetics and Bayesian Estimation of Mycophenolic Acid Exposure in Chinese Renal Allograft Recipients After Administration of EC-MPS

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2019; 59 (4)

The aim of the present study is to establish a population pharmacokinetic (PPK) model of mycophenolic acid (MPA) and limited sampling strategy models ......

JIF:2.91

Population Pharmacokinetic Study and Individual Dose Adjustments of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia or Osteosarcoma

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2019; 59 (4)

High-dose methotrexate (>0.5g/m(2)) is among the first-line chemotherapeutic agents used in treating acute lymphoblastic leukemia (ALL) and osteosa......

JIF:2.91

Accurate Prediction of Initial Busulfan Exposure Using a Test Dose With 2-and 6-Hour Blood Sampling in Adult Patients Receiving a Twice-Daily Intravenous Busulfan-Based Conditioning Regimen

期刊: JOURNAL OF CLINICAL PHARMACOLOGY, 2019; 59 (5)

This study aimed to predict the area under the curve (AUC) of the initial busulfan dose using a test dose with the sparse sampling scheme in adult pat......

JIF:2.91

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