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Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 209 ()

Inhibition of Poly(ADP-ribose) polymerase (PARP) is effective for breast cancer susceptibility genes 1 (BRCA1)deficient breast cancers. Although hormo......

Association of 25-hydroxyvitamin D level with survival outcomes in female breast cancer patients: A meta-analysis

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 212 ()

Conflicting results have been reported on the association of blood vitamin D level with prognosis in women with breast cancer. This meta-analysis aime......

Relationship between lipid metabolism and Hedgehog signaling pathway

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 209 ()

The Hedgehog (Hh) signaling pathway is highly conserved signaling pathway in cells. Steroids was found to play a vital role in Hh signaling pathway an......

miR-130b-3p is high-expressed in polycystic ovarian syndrome and promotes granulosa cell proliferation by targeting SMAD4

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 209 ()

Background: Being one of the most prevalent metabolic and endocrine disorders, Polycystic Ovary Syndrome (PCOS) has been proven to be associated with ......

The ER beta-CXCL19/CXCR4-NF kappa B pathway is critical in mediating the E2-induced inflammation response in the orange-spotted grouper (Epinephelus coioides)

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 212 ()

The main physiological function of 17 beta-estradiol (E2) in vertebrates is to regulate sexual development and reproduction. In fish, especially herma......

?-Tocotrienol reverses multidrug resistance of breast cancer cells through the regulation of the ?-Tocotrienol-NF-?B-P-gp axis

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 209 ()

The problem of multidrug resistance (MDR) presents a major obstacle in the chemotherapy of cancer. The MDR phenotype is often linked to the overexpres......

Evaluation of vitamin D storage in patients with chronic kidney disease: Detection of serum vitamin D metabolites using high performance liquid chromatography-tandem mass spectrometry

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 210 ()

Background: Vitamin D (VitD) deficiency is extremely common in chronic kidney disease (CKD). However, the current clinical testing of vitamin D is bas......

Calcitriol promotes the maturation of hepatocyte-like cells derived from human pluripotent stem cells

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 211 ()

Human hepatocyte-like cells (HLCs) derived from human pluripotent stem cells (hPSCs) represent a promising cell source for the assessment of hepatotox......

Elucidation of the mechanism of NEFA-induced PERK-eIF2 alpha signaling pathway regulation of lipid metabolism in bovine hepatocytes

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 211 ()

During the periparturient transition period, negative energy balance (NEB) characterized by high concentrations of non-esterified fatty acids (NEFA) m......

Reference values for free 25-hydroxy-vitamin D based on established total 25-hydroxy-vitamin D reference values

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 210 ()

Measurements of total 25-hydroxyvitamin D (t25(OH)D) are currently primarily used to assess the vitamin D status. The lipophilic cell membrane can onl......

Targeted gene panel sequencing for molecular diagnosis of congenital adrenal hyperplasia

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 211 ()

Context: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive genetic diseases caused by genetic deficiency in nine genes encoding s......

Characteristics of steroidogenesis-related factors in the musk gland of Chinese forest musk deer (Moschus berezovskii)

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 212 ()

Musk secreted by Chinese forest musk deer (FMD; Moschus berezovskii) is a highly valuable ingredient in the fields of perfumery and medicine, and the ......

1?,25-dihydroxyvitamin D3 promotes early osteogenic differentiation of PDLSCs and a 12-year follow-up case of early-onset vitamin D deficiency periodontitis

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 208 ()

Periodontitis is a chronic periodontal disease that contributes to tooth loss. In recent years, many animal studies have reported that vitamin D (VitD......

Compound heterozygosity of a novel Q73X mutation and a known R141X mutation in CYP11B1 resulting in 11 beta-hydroxylase deficiency in a Chinese boy with congenital adrenal hyperplasia

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 211 ()

Steroid 11 beta-hydroxylase deficiency (1113- OHD), which is caused by mutations of the CYP11B1 gene, is the second leading cause of congenital adrena......

17 beta-estradiol improves the developmental ability, inhibits reactive oxygen species levels and apoptosis of porcine oocytes by regulating autophagy events

期刊: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2021; 209 ()

Objectives: Estrogen plays a critical role in the development and apoptosis of oocytes. Autophagy is an evolutionarily conserved and exquisitely regul......

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