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RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation

期刊: NEUROBIOLOGY OF DISEASE, 2021; 156 ()

Cerebrovascular remodeling is the most common cause of hypertension and stroke. Ubiquitin E3 ligase RING finger protein 34 (RNF34) is suggested to be ......

ALS-causing SOD1 mutants regulate occludin phosphorylation/ ubiquitination and endocytic trafficking via the ITCH/Eps15/Rab5 axis

期刊: NEUROBIOLOGY OF DISEASE, 2021; 153 ()

It is increasingly recognized that blood-spinal cord barrier (BSCB) breakdown is a hallmark of amyotrophic lateral sclerosis (ALS). BSCB integrity is ......

Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice

期刊: NEUROBIOLOGY OF DISEASE, 2021; 156 ()

Stroke is one of the leading causes of death worldwide, with intracerebral hemorrhage (ICH) being the most lethal subtype. Neuritin (Nrn) is a neurotr......

Sensorineural hearing loss may lead to dementia-related pathological changes in hippocampal neurons

期刊: NEUROBIOLOGY OF DISEASE, 2021; 156 ()

Presbycusis contributes to cognitive decline and Alzheimer's disease. However, most research in this area involves clinical observations and statistic......

Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice

期刊: NEUROBIOLOGY OF DISEASE, 2021; 156 ()

In view of the negative regulatory effect of leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO-......

Low-frequency oscillations in cortical level to help diagnose task-specific dystonia

期刊: NEUROBIOLOGY OF DISEASE, 2021; 157 ()

Task-specific dystonia is a neurological movement disorder that abnormal contractions of muscles result in the twisting of fixed postures or muscle sp......

Local field potentials in Parkinson's disease: A frequency-based review

期刊: NEUROBIOLOGY OF DISEASE, 2021; 155 ()

Deep brain stimulation (DBS) surgery offers a unique opportunity to record local field potentials (LFPs), the electrophysiological population activity......

Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP

期刊: NEUROBIOLOGY OF DISEASE, 2021; 153 ()

Vacuolar protein sorting protein 35 (VPS35) is a core component of the retromer complex involved in regulating protein trafficking and retrieval. Rece......

Increased ATP release and CD73-mediated adenosine A(2A) receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction

期刊: NEUROBIOLOGY OF DISEASE, 2021; 157 ()

Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellul......

Linking cortical astrocytic neogenin deficiency to the development of Moyamoya disease?like vasculopathy

期刊: NEUROBIOLOGY OF DISEASE, 2021; 154 ()

Moyamoya-like vasculopathy, the ?puff of smoke?-like small vessels in the brain, is initially identified in patients with Moyamoya disease (MMD), a ra......

Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson?s disease

期刊: NEUROBIOLOGY OF DISEASE, 2021; 154 ()

Parkinson?s disease (PD) is one of the most common neurodegenerative diseases, which is characterized by the loss of dopaminergic neurons in the nigro......

Indoles as essential mediators in the gut-brain axis. Their role in Alzheimer's disease

期刊: NEUROBIOLOGY OF DISEASE, 2021; 156 ()

Sporadic late-onset Alzheimer's disease (AD) is the most frequent cause of dementia associated with aging. Due to the progressive aging of the populat......

Evaluation of blood flow as a route for propagation in experimental synucleinopathy

期刊: NEUROBIOLOGY OF DISEASE, 2021; 150 ()

In Parkinson's disease, synucleinopathy is hypothesized to spread from the enteric nervous system, via the vagus nerve, to the central nervous system.......

Cholesterol synthesis inhibition promotes axonal regeneration in the injured central nervous system

期刊: NEUROBIOLOGY OF DISEASE, 2021; 150 ()

Neuronal regeneration in the injured central nervous system is hampered by multiple extracellular proteins. These proteins exert their inhibitory acti......

Spinophilin modulates pain through suppressing dendritic spine morphogenesis via negative control of Rac1-ERK signaling in rat spinal dorsal horn

期刊: NEUROBIOLOGY OF DISEASE, 2021; 152 ()

Both spinophilin (SPN, also known as neurabin 2) and Rac1 (a member of Rho GTPase family) are believed to play key roles in dendritic spine (DS) remod......

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