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One year of SARS-CoV-2 evolution

期刊: CELL HOST & MICROBE, 2021; 29 (4)

Since the outbreak of SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, the viral genome has acquired numerous mutations with the potential to......

Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

期刊: CELL HOST & MICROBE, 2021; 29 (4)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by a burst in the upper respiratory portal for high transmissibility. To......

Microbiota regulate innate immune signaling and protective immunity against cancer

期刊: CELL HOST & MICROBE, 2021; 29 (6)

Microbiota play critical roles in regulating colitis and colorectal cancer (CRC). However, it is unclear how the microbiota generate protective immuni......

Rethinking phage-bacteria-eukaryotic relationships and their influence on human health

期刊: CELL HOST & MICROBE, 2021; 29 (5)

There is a rapidly growing body of research demonstrating the unique and often surprising mechanisms by which bacteriophages, specialized viruses of b......

Developmental trajectory of the healthy human gut microbiota during the first 5 years of life

期刊: CELL HOST & MICROBE, 2021; 29 (5)

The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is established at birth. However, the succession by which different ba......

Western diet induces Paneth cell defects through microbiome alterations and farnesoid X receptor and type I interferon activation

期刊: CELL HOST & MICROBE, 2021; 29 (6)

Intestinal Paneth cells modulate innate immunity and infection. In Crohn's disease, genetic mutations together with environmental triggers can disable......

Bacteria induce skin regeneration via IL-1 beta signaling

期刊: CELL HOST & MICROBE, 2021; 29 (5)

Environmental factors that enhance regeneration are largely unknown. The immune system and microbiome are attributed roles in repairing and regenerati......

Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

期刊: CELL HOST & MICROBE, 2021; 29 (2)

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV......

Giant DNA viruses make big strides in eukaryote evolution

期刊: CELL HOST & MICROBE, 2021; 29 (2)

Nucleocytoplasmic large DNA viruses (NCLDVs) are widespread in the biosphere. This issue of Cell Host & Microbe, Nelson et al., and a recent Natur......

Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

期刊: CELL HOST & MICROBE, 2021; 29 (3)

The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. Here, we utilized an integrative approach combining epidemiolo......

Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating

期刊: CELL HOST & MICROBE, 2021; 29 (3)

Enterovirus uncoating receptors bind at the surface depression ("canyon'') that encircles each capsid vertex causing the release of a host-derived lip......

lncRNA Sensing of a Viral Suppressor of RNAi Activates Non-canonical Innate Immune Signaling in Drosophila

期刊: CELL HOST & MICROBE, 2020; 27 (1)

Antiviral immunity in insects is mediated by the RNA interference (RNAi) pathway. Viruses evade antiviral RNAi by expressing virulence factors known a......

Staphylococcus epidermidis Contributes to Healthy Maturation of the Nasal Microbiome by Stimulating Antimicrobial Peptide Production

期刊: CELL HOST & MICROBE, 2020; 27 (1)

The composition of the human microbiome profoundly impacts human well-being. However, the mechanisms underlying microbiome maturation are poorly under......

Identification of Antibodies with Non-overlapping Neutralization Sites that Target Coxsackievirus A16

期刊: CELL HOST & MICROBE, 2020; 27 (2)

Hand, foot, and mouth disease is a common childhood illness primarily caused by coxsackievirus A16 (CVA16), for which there are no current vaccines or......

A Bartonella Effector Acts as Signaling Hub for Intrinsic STAT3 Activation to Trigger Anti-inflammatory Responses

期刊: CELL HOST & MICROBE, 2020; 27 (3)

Chronically infecting pathogens avoid clearance by the innate immune system by promoting premature transition from an initial pro-inflammatory respons......

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