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Updating the International IgA Nephropathy Prediction Tool for use in children

期刊: KIDNEY INTERNATIONAL, 2021; 99 (6)

Although IgA nephropathy (IgAN) is a common cause of glomerulonephritis in children, the absence of a method to predict disease progression limits per......

Receptor activator of NF-kappa B mediates podocyte injury in diabetic nephropathy

期刊: KIDNEY INTERNATIONAL, 2021; 100 (2)

Receptor activator of NF-kappa B (RANK) expression is increased in podocytes of patients with diabetic nephropathy. However, the relevance of RANK to ......

A pre-specified analysis of the DAPA-CKD trial demonstrates the effects of dapagliflozin on major adverse kidney events in patients with IgA nephropathy

期刊: KIDNEY INTERNATIONAL, 2021; 100 (1)

Immunoglobulin A (IgA) nephropathy is a common form of glomerulonephritis, which despite use of renin-angiotensin-aldosterone-system blockers and immu......

Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy

期刊: KIDNEY INTERNATIONAL, 2021; 100 (1)

Since failed resolution of inflammation is a major contributor to the progression of diabetic nephropathy, identifying endogenously generated molecule......

Hyperphosphatemia in chronic kidney disease exacerbates atherosclerosis via a mannosidases-mediated complex-type conversion of SCAP N-glycans

期刊: KIDNEY INTERNATIONAL, 2021; 99 (6)

Blood phosphate levels are linked to atherosclerotic cardiovascular disease in patients with chronic kidney disease (CKD), but the molecular mechanism......

Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

期刊: KIDNEY INTERNATIONAL, 2021; 100 (3)

Kidney fibrosis constitutes the shared final pathway of nearly all chronic nephropathies, but biomarkers for the non-invasive assessment of kidney fib......

Stabilization of hypoxia-inducible factor ameliorates glomerular injury sensitization after tubulointerstitial injury

期刊: KIDNEY INTERNATIONAL, 2021; 99 (3)

Previously, we found that mild tubulointerstitial injury sensitizes glomeruli to subsequent injury. Here, we evaluated whether stabilization of hypoxi......

A study from The Mayo Clinic evaluated long-term outcomes of kidney transplantation in patients with immunoglobulin light chain amyloidosis

期刊: KIDNEY INTERNATIONAL, 2021; 99 (3)

Longer survival using modern therapies has increased the number of patients with immunoglobulin light-chain amyloidosis receiving kidney transplantati......

Executive summary of the KDIGO 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease

期刊: KIDNEY INTERNATIONAL, 2021; 99 (3)

The Kidney Disease: Improving Global Outcomes (KDIGO) 2021 Clinical Practice Guideline for the Management of Blood Pressure in Chronic Kidney Disease ......

Cannabinoid receptor type 2 promotes kidney fibrosis through orchestrating beta-catenin signaling

期刊: KIDNEY INTERNATIONAL, 2021; 99 (2)

The endocannabinoid system has multiple effects. Through interacting with cannabinoid receptor type 1 and type 2, this system can greatly affect disea......

Living well with kidney disease by patient and care-partner empowerment: kidney health for everyone everywhere

期刊: KIDNEY INTERNATIONAL, 2021; 99 (2)

Living with chronic kidney disease (CKD) is associated with hardships for patients and their care partners. Empowering patients and their care partner......

Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

期刊: KIDNEY INTERNATIONAL, 2021; 99 (4)

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-se......

Low expression of HIV genes in podocytes accelerates the progression of diabetic kidney disease in mice

期刊: KIDNEY INTERNATIONAL, 2021; 99 (4)

With the widespread use combination antiretroviral therapy, there has been a dramatic decrease in HIV-associated nephropathy. However, although the pa......

Reduced Lon protease 1 expression in podocytes contributes to the pathogenesis of podocytopathy

期刊: KIDNEY INTERNATIONAL, 2021; 99 (4)

Emerging evidence has shown that mitochondrial dysfunction is closely related to the pathogenesis of podocytopathy, but the molecular mechanisms media......

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