期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021; 17 (6)
Introduction: Cytochrome P450 (CYP) is a monooxygenase superfamily mediating the elimination of anti-hypertensive drugs. Polymorphisms of CYP would le......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021; 17 (9)
Introduction The first-in-class BTK inhibitor ibrutinib has substantially changed the therapeutic landscape of chronic lymphocytic leukemia (CLL). The......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021; 17 (6)
Background Dipeptidyl peptidase-4 (DPP-4) inhibitors have significant clinical efficacy for type 2 diabetes mellitus (T2DM). The combination of fotagl......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021; 17 (9)
Purpose: To compare the pharmacokinetics, pharmacodynamics and safety of the new prolongedrelease leuprorelin acetate microspheres for injection (3.75......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021; 17 (9)
Introduction Although dabigatran is safer than vitamin K antagonists, bleeding still occurs. Bleeding is an important cause of short-term morbidity an......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021; 17 (7)
Introduction Cytosolic sulfotransferases (SULTs)-mediated sulfation is critically involved in the metabolism of key endogenous compounds, such as cate......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2021; 17 (9)
Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining the ionization of a drug in the human body. The Henderson-H......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, ; ()
Objective To evaluate the effect of food on the pharmacokinetics (PK) of fluzoparib capsule. Methods PK data were obtained after fluzoparib treatment ......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, ; ()
Background: Erythropoietin (EPO) plays a substantial role in cancer development and probably affects clinical outcomes. A functional polymorphism (rs1......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, ; ()
Introduction Multi-drug resistance (MDR) is a hindrance toward the successful treatment of cancers. The primary mechanism that gives rise to acquired ......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, ; ()
Introduction: The CD47 and SIRP alpha checkpoint pathway has garnered much interest within the anti-cancer research community, with multiple experimen......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2020; 16 (9)
Introduction Vascular endothelial growth factor (VEGF) is a key target in cancer therapy. However, cardiovascular safety has been one of the most chal......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2020; 16 (8)
Introduction Phenytoin is a frequently used drug treatment for epilepsy. Genetic polymorphisms in the metabolism of phenytoin, particularlyCYP2C9, are......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2020; 16 (9)
Introduction Statins have been established as the standard of care for dyslipidemia and preventing cardiovascular diseases while posing few safety con......
期刊： EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2020; 16 (10)
Objectives This study aimed to evaluate the bioequivalence, safety, tolerability and immunogenicity of the biosimilar trastuzumab (SIBP-01) compared t......
