期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (8)
CYP1A2, as one of the most important cytochrome P450 isoforms, is involved in the biotransformation of many important endogenous and exogenous substan......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (9)
Silybin is widely used as a hepatoprotective agent in various liver disease therapies and has been previously identified as a CYP3A inhibitor. However......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (9)
For drug development, species differences in drug-metabolism reactions present obstacles for predicting pharmacokinetics in humans. We characterized t......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (5)
Deoxycholic acid (DCA, 3 alpha, 12 alpha-dihydroxy-5 beta-cholan-24-oic acid) is the major circulating secondary bile acid, which is synthesized by gu......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (5)
As a partner antimalarial with an extremely long elimination half-life (similar to 30 days), piperaquine (PQ) is mainly metabolized into a pharmacolog......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (6)
Methylophiopogonanone A (MOA), an abundant homoisoflavonoid bearing a methylenedioxyphenyl moiety, is one of the major constituents in the Chinese her......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (5)
Literature reports that Poria cocos reduces blood lipid levels; however, the underlying mechanism remains unclear. Blood lipid levels are closely rela......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (4)
To develop a functional alternative hepatocyte model for primary human hepatocytes (PHHs) with proliferative property, essential drug metabolic, and t......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (5)
Y The maintenance of homeostasis of cytochromes P450 enzymes (P450s) under both physiologic and xenobiotic exposure conditions is ensured by the actio......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (1)
Physiologically based pharmacokinetic modeling has become a standard tool to predict drug distribution in early stages of drug discovery; however, thi......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (1)
Individual variations in xenobiotic metabolism affect the sensitivity to diseases. In this study, the impacts of sex, age, and race/ethnicity on drug-......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (1)
Diet is an important factor for many diseases. Previous studies have demonstrated that several diets had remarkable effects on bile acid (BA) homeosta......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (2)
Suspended, plated, or sandwich-cultured human hepatocytes are routinely used for in vitro to in vivo extrapolation (IVIVE) of transporter-mediated hep......
期刊： DRUG METABOLISM AND DISPOSITION, 2021; 49 (3)
Our previous study suggests that berberine (BBR) lowers lipids by modulating bile acids and activating intestinal farnesoid X receptor (FXR). However,......
期刊： DRUG METABOLISM AND DISPOSITION, 2020; 48 (8)
UDP-glucuronosyltransferases (UGTs) are a family of phase II enzymes that play an important role in metabolism and elimination of numerous endo- and x......
