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Improving antitumor immunity using antiangiogenic agents: Mechanistic insights, current progress, and clinical challenges

期刊: CANCER COMMUNICATIONS, 2021; 41 (9)

Cancer immunotherapy, especially immune checkpoint blockade (ICB), has revolutionized oncology. However, only a limited number of patients benefit fro......

Advancing to the era of cancer immunotherapy

期刊: CANCER COMMUNICATIONS, 2021; 41 (9)

Cancer greatly affects the quality of life of humans worldwide and the number of patients suffering from it is continuously increasing. Over the last ......

Mitochondrial transcription factor A plays opposite roles in the initiation and progression of colitis-associated cancer

期刊: CANCER COMMUNICATIONS, 2021; 41 (8)

Background Mitochondria are key regulators in cell proliferation and apoptosis. Alterations in mitochondrial function are closely associated with infl......

Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C

期刊: CANCER COMMUNICATIONS, 2021; 41 (7)

Background Multiple myeloma (MM) is a hematologic malignancy characterized by the accumulation of aberrant plasma cells within the bone marrow. The hi......

Nuclear Aurora kinase A triggers programmed death-ligand 1-mediated immune suppression by activating MYC transcription in triple-negative breast cancer

期刊: CANCER COMMUNICATIONS, 2021; 41 (9)

Background Increasing studies have reported that oncogenes regulate components of the immune system, suggesting that this is a mechanism for tumorigen......

Improved esophageal squamous cell carcinoma screening effectiveness by risk-stratified endoscopic screening: evidence from high-risk areas in China

期刊: CANCER COMMUNICATIONS, 2021; 41 (8)

Background Risk-stratified endoscopic screening (RSES), which offers endoscopy to those with a high risk of esophageal cancer, has the potential to in......

Meiotic nuclear divisions 1 (MND1) fuels cell cycle progression by activating a KLF6/E2F1 positive feedback loop in lung adenocarcinoma

期刊: CANCER COMMUNICATIONS, 2021; 41 (6)

BackgroundConsidering the increase in the proportion of lung adenocarcinoma (LUAD) cases among all lung cancers and its considerable contribution to c......

The role of the HIF-1 alpha/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer

期刊: CANCER COMMUNICATIONS, 2021; 41 (7)

Background: As a rate-limiting enzyme of glycolysis, pyruvate kinase muscle isozyme M2 (PKM2) participates in tumor metabolism and growth. The regulat......

Intra-heterogeneity in transcription and chemoresistant property of leukemia-initiating cells in murine Setd2(-/-) acute myeloid leukemia

期刊: CANCER COMMUNICATIONS, 2021; 41 (9)

Background Heterogeneity of leukemia-initiating cells (LICs) is a major obstacle in acute myeloid leukemia (AML) therapy. Accumulated evidence indicat......

Programmed death ligand-1 regulates angiogenesis and metastasis by participating in the c-JUN/VEGFR2 signaling axis in ovarian cancer

期刊: CANCER COMMUNICATIONS, 2021; 41 (6)

Background Although programmed cell death-ligand 1 (PD-L1) plays a well-known function in immune checkpoint response by interacting with programmed ce......

Neoadjuvant immunotherapy for non-small cell lung cancer: State of the art

期刊: CANCER COMMUNICATIONS, 2021; 41 (4)

Lung cancer mortality has decreased over the past decade and can be partly attributed to advances in targeted therapy and immunotherapy. Immune checkp......

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling

期刊: CANCER COMMUNICATIONS, 2021; 41 (8)

Background Colorectal cancer (CRC) is one of the most malignant tumors with high incidence, yet its molecular mechanism is not fully understood, hinde......

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