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PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IR beta axis during overnutrition

期刊: MOLECULAR METABOLISM, 2022; 65 ()

Objective: Pituitary adenylate cyclase-activating polypeptide (PACAP) was reported to attenuate hepatic lipid accumulation in overnutrition-related me......

JIF:6.858

Autotaxin signaling facilitates (3 cell dedifferentiation and dysfunction induced by Sirtuin 3 deficiency

期刊: MOLECULAR METABOLISM, 2022; 60 ()

Objective: (3 cell dedifferentiation may underlie the reversible reduction in pancreatic (3 cell mass and function in type 2 diabetes (T2D). We previo......

JIF:6.858

CLSTN3 gene variant associates with obesity risk and contributes to dysfunction in white adipose tissue

期刊: MOLECULAR METABOLISM, 2022; 63 ()

Objective:White adipose tissue (WAT) possesses the remarkable remodeling capacity, and maladaptation of this ability contributes to the development of......

JIF:6.858

Role and mechanism of ferroptosis in neurological diseases

期刊: MOLECULAR METABOLISM, 2022; 61 ()

Background: Ferroptosis, as a new form of cell death, is different from other cell deaths such as autophagy or senescence. Ferroptosis involves in the......

JIF:6.858

A novel lncRNA RP11-386G11.10 reprograms lipid metabolism to promote hepatocellular carcinoma progression

期刊: MOLECULAR METABOLISM, 2022; 63 ()

Objective: Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in hepatocellular carcinoma (HCC). A rapidly increasing num......

JIF:6.858

What role does pyroptosis play in cancer?

期刊: MOLECULAR METABOLISM, 2022; 65 ()

Background: Pyroptosis has been attracting much attention recently. We have briefly compared its differences and similarities with other programmed de......

JIF:6.858

Neuronal miR-29a protects from obesity in adult mice

期刊: MOLECULAR METABOLISM, 2022; 61 ()

Objective: Obesity, a growing threat to the modern society, represents an imbalance of metabolic queues that normally signal to the arcuate hypothalam......

JIF:6.858

Empagliflozin activates Wnt/beta-catenin to stimulate FUNDC1-dependent mitochondrial quality surveillance against type-3 cardiorenal syndrome

期刊: MOLECULAR METABOLISM, 2022; 64 ()

Objectives: Cardiorenal syndrome type-3 (CRS-3) is an abrupt worsening of cardiac function secondary to acute kidney injury. Mitochondrial dysfunction......

JIF:6.858

Carboxylesterase 2 induces mitochondrial dysfunction via disrupting lipid homeostasis in oral squamous cell carcinoma

期刊: MOLECULAR METABOLISM, 2022; 65 ()

Objective: Oral squamous cell carcinoma (OSCC) is characterized by high recurrence and metastasis and places a heavy burden on societies worldwide. Ca......

JIF:6.858

Noncoding RNAs from tissue-derived small extracellular vesicles: Roles in diabetes and diabetic complications

期刊: MOLECULAR METABOLISM, 2022; 58 ()

Diabetes is a systemic disease, and its progression involves multiple organ dysfunction. However, the exact mechanisms underlying pathological progres......

JIF:6.858

Effects of ambient temperatures between 5 and 35 degrees C on energy balance, body mass and body composition in mice

期刊: MOLECULAR METABOLISM, 2022; 64 ()

Background: Considerable attention is currently focused on the potential to switch on brown adipose tissue (BAT), or promote browning of white adipose......

JIF:6.858

Serum amyloid A1 exacerbates hepatic steatosis via TLR4-mediated NF-KB signaling pathway

期刊: MOLECULAR METABOLISM, 2022; 59 ()

Objective: Chronic inflammatory response plays a prominent role in obesity-related nonalcoholic fatty liver disease (NAFLD). However, the intrahepatic......

JIF:6.858

Ferroptosis and ferritinophagy in diabetes complications

期刊: MOLECULAR METABOLISM, 2022; 60 ()

Background: With long-term metabolic malfunction, diabetes can cause serious damage to whole-body tissue and organs, resulting in a variety of complic......

JIF:6.858

Reprogramming hormone-sensitive prostate cancer to a lethal neuroendocrine cancer lineage by mitochondrial pyruvate carrier (MPC)

期刊: MOLECULAR METABOLISM, 2022; 59 ()

Cell lineage reprogramming is the main approach for cancer cells to acquire drug resistance and escape targeted therapy. The use of potent targeted th......

JIF:6.858

New dawn for cancer cell death: Emerging role of lipid metabolism

期刊: MOLECULAR METABOLISM, 2022; 63 ()

Background: Resistance to cell death, a protective mechanism for removing damaged cells, is a Hallmark of Cancer that is essential for cancer progress......

JIF:6.858

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