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High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (8)

Head and neck paragangliomas (HNPGLs) are rare neoplasms that represent difficult treatment paradigms in neurotology. Germline mutations in genes enco......

Low prevalence and independent prognostic role of del(11q) in Chinese patients with chronic lymphocytic leukemia

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (10)

The 11q deletion (del(11q)) is a conventional cytogenetic aberration observed in chronic lymphocytic leukemia (CLL) patients. However, the prevalence ......

The role of exosomal PD-L1 in tumor immunotherapy

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (5)

Exosomes are bioactive lipid bilayer vesicles released by most cells to mediate intercellular signal communication. Tumor cells release exosomes trans......

Metaplastic breast cancer: Treatment and prognosis by molecular subtype

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (5)

Background: Metaplastic breast cancer (MBC) is a rare and aggressive subtype of breast. However, the effect of molecular subtype on treatment and prog......

SOS1 promotes epithelial-mesenchymal transition of Epithelial Ovarian Cancer(EOC) cells through AKT independent NF-kB signaling pathway

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (9)

We aimed to explore the role and mechanism of SOS1 (Son of sevenless homolog 1) in malignant behaviors of epithelial ovarian cancer (EOC) cells Hey wi......

OLFML2A is necessary for anti-triple negative breast cancer effect of selective activator protein-1 inhibitor T-5224

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (8)

Previous studies have shown that expression of activator protein-1 (AP-1) family is significantly elevated in triple negative breast cancer (TNBC), co......

The efficacy and safety of antibodies targeting PD-1 for treatment in advanced esophageal cancer: A systematic review and meta-analysis

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (6)

Background: A novel therapy based on programmed death 1 (PD-1) inhibitors has been proved to be effective in advanced esophageal cancer. This article ......

Novel artificial intelligence machine learning approaches to precisely predict survival and site-specific recurrence in cervical cancer: A multi-institutional study

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (5)

Background: Machine learning (ML) has been gradually integrated into oncologic research but seldom applied to predict cervical cancer (CC), and no mod......

The prognostic value of circulating tumor DNA in patients with melanoma: A systematic review and meta-analysis

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (6)

Background: Circulating tumor DNA (ctDNA) has been investigated as a potential prognostic biomarker to evaluate the therapeutic efficacy and disease p......

Knockdown of CDK5 down-regulates PD-L1 via the ubiquitination-proteasome pathway and improves antitumor immunity in lung adenocarcinoma

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (9)

Although immunotherapy (anti-PD-1/PD-L1 antibodies) has been approved for clinical treatment of lung cancer, only a small proportion of patients respo......

Obatoclax, the pan-Bcl-2 inhibitor sensitizes hepatocellular carcinoma cells to promote the anti-tumor efficacy in combination with immune checkpoint blockade

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (8)

Bcl-2 family proteins play critical roles in regulating lymphocyte development and maintain homeostasis, and have also been proved to be involved in v......

Clinicopathological characteristics of androgen receptor splicing variant 7 (AR-V7) expression in patients with castration resistant prostate cancer: A systematic review and meta-analysis

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (9)

Background: Studies have shown that AR-V7 may be correlated with the poor prognosis of castration resistant prostate cancer (CRPC), however, clinicopa......

Amplification of RAD54B promotes progression of hepatocellular carcinoma via activating the Wnt/beta-catenin signaling

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (8)

Liver cancer was reported to be the sixth most frequently diagnosed cancer, and hepatocellular carcinoma (HCC) accounts for 75%-85% of primary liver c......

Synergic radiosensitization of sinomenine hydrochloride and radioiodine on human papillary thyroid carcinoma cells

期刊: TRANSLATIONAL ONCOLOGY, 2021; 14 (10)

Radioiodine (I-131) therapy is an important treatment for thyroid carcinoma. The response to radiotherapy sometimes limited by the development of radi......

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