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Serum insulin-like growth factor binding protein 3 as a promising diagnostic and prognostic biomarker in esophagogastric junction adenocarcinoma

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Background Esophagogastric junction adenocarcinoma (EJA) lacks serum biomarkers to assist in diagnosis and prognosis. Here, we aimed to evaluate the d......

Identification and validation of a novel cuproptosis-related lncRNA gene signature to predict prognosis and immune response in bladder cancer

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Purpose Bladder cancer (BCa) is one of the most common malignant tumors in the urogenital system, characterized by the high recurrence rate, mortality......

PAIP1 is a novel oncogene in human hepatocellular carcinoma

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Background Poly(A)-binding protein interacting protein 1 (PAIP1) is a translational initiation regulatory factor that has been reported as oncogene in......

CD155 promotes radioresistance and malignancy of esophageal cancer by regulating Hippo-YAP pathway

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

The expression of CD155 has been observed to increase in various human cancers, but its role in the development of esophageal cancer (EC) is unclear. ......

LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Pancreatic cancer is the leading cause of cancer-related mortality because of tumor metastasis. Activation of the epithelial-to-mesenchymal transition......

Integrated in silico analysis of LRP2 mutations to immunotherapy efficacy in pan-cancer cohort

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Purpose Immunotherapy has emerged as a novel therapy, while many patients are refractory. Although, several biomarkers have been identified as predict......

L718Q/V mutation in exon 18 of EGFR mediates resistance to osimertinib: clinical features and treatment

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Osimertinib, a mutant-specific third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is emerging as the preferred ......

The relationship of serum gastrin-17 and oral mucositis in head and neck carcinoma patients receiving radiotherapy

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Objective The aim of this study was to analyze the relationship of serum gastrin-17 (G-17) and oral mucositis in head and neck carcinoma (HNC) patient......

Timing of additional neoadjuvant chemotherapy in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy and total mesorectal excision

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Background In locally advanced rectal cancer (LARC), the optimal sequence of neoadjuvant chemotherapy in relation to neoadjuvant chemoradiotherapy and......

Programmed death-ligand 1 and mammalian target of rapamycin signaling pathway in locally advanced rectal cancer

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Purpose To evaluate the role of programmed death-ligand 1 (PD-L1) and mammalian target of rapamycin (mTOR) signaling pathway in locally advanced recta......

Pan-cancer analysis of necroptosis-related gene signature for the identification of prognosis and immune significance

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Background Necroptosis is a novel programmed cell death mode independent on caspase. A number of studies have revealed that the induction of necroptos......

KLF14 targets ITGB1 to inhibit the progression of cervical cancer via the PI3K/AKT signalling pathway

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Our study aimed to determine whether Kruppel-like factor 14 (KLF14) inhibits the proliferation and promotes the apoptosis of cervical cancer cells thr......

miRNA-23b-5p affects the proliferation, migration and invasion of osteosarcoma by targeting TMEM127

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

Background Osteosarcoma (OS) has become one of the highest mortality cancers in the world due to its late diagnosis, rapid metastasis and rapid recurr......

Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis

期刊: DISCOVER ONCOLOGY, 2022; 13 (1)

CircRNAs have been found to play crucial roles in the metabolism and progression of cancers, but their roles and mechanisms in esophageal squamous cel......

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