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Stromal infiltrating mast cells identify immunoevasive subtype high-grade serous ovarian cancer with poor prognosis and inferior immunotherapeutic response

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Tumor infiltrating mast cells (TIMs), with pro- or anti-tumorigenic role in different types of malignancies, have been implicated in resistance to ant......

Low-dose HDACi potentiates anti-tumor activity of macrophages in immunotherapy

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

The success of checkpoint immunotherapy has created optimism that cancer may be curable. However, not all patients respond, resistance is common and m......

VISTA and PD-L1 synergistically predict poor prognosis in patients with extranodal natural killer/T-cell lymphoma

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Although PD-1/PD-L1 blockade therapy confers salutary effects across cancer types, their efficacy in Extranodal Natural killer/T-cell lymphoma (ENKTCL......

PD-L2 based immune signature confers poor prognosis in HNSCC

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

PD-L2 expression is an important predictor of anti-PD-1 therapy efficacy in patients with head and neck squamous cell carcinoma (HNSCC). However, whet......

Alternol triggers immunogenic cell death via reactive oxygen species generation

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Alternol is a naturally occurring compound that exerts antitumor activity in several cancers. However, whether Alternol induces antitumor immune respo......

Identification and characterization of B220(+)/B220(-) subpopulations in murine Gr1(+)CD11b(+) cells during tumorigenesis

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Although all murine MDSCs are defined as Gr1(+)CD11b(+), their true immunophenotype remains elusive. In this study, we found murine Gr1(+)CD11b(+) cel......

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we re......

Antitumor activity of the third generation EphA2 CAR-T cells against glioblastoma is associated with interferon gamma induced PD-L1

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Glioblastoma (GBM) is the most common and aggressive brain malignancy in adults and is currently incurable with conventional therapies. The use of chi......

Effects of concomitant proton pump inhibitor use on immune checkpoint inhibitor efficacy among patients with advanced cancer

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Background The present study aimed to evaluate the effects of concomitant proton pump inhibitor (PPI) use on immune checkpoint inhibitor (ICI) efficac......

Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Immunotherapy that block PD-1-PD-L1 pathway can induce durable tumor control and result in the long-term survival of patients with advanced bladder ca......

The effect of concomitant use of statins, NSAIDs, low-dose aspirin, metformin and beta-blockers on outcomes in patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Immunotherapy shows promising therapeutic efficacy against various types of cancer, but most fail to respond. Preclinical studies have suggested that ......

YKT6, as a potential predictor of prognosis and immunotherapy response for oral squamous cell carcinoma, is related to cell invasion, metastasis, and CD8+T cell infiltration

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Metastasis and immune suppression account for the poor prognosis of oral squamous cell carcinoma (OSCC). YKT6 is a member of the soluble NSF attachmen......

Characterization of immune landscape in papillary thyroid cancer reveals distinct tumor immunogenicity and implications for immunotherapy

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Although the vast majority of patients with papillary thyroid cancer (PTC) have a favorable prognosis when conventional treatments are implemented, lo......

Double-edged effects of interferons on the regulation of cancer-immunity cycle

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Interferons (IFNs) are a large family of pleiotropic cytokines that regulate both innate and adaptive immunity and show anti-cancer effects in various......

Development of a novel gene signature to predict prognosis and response to PD-1 blockade in clear cell renal cell carcinoma

期刊: ONCOIMMUNOLOGY, 2021; 10 (1)

Clear cell renal cell carcinoma (ccRCC) is the most common kidney malignancy characterized by a poor prognosis. The treatment efficacy of immune check......

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