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Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Adiponectin is a small peptide secreted and a key component of the endocrine system and immune system. Although globular adiponectin protects myocardi......

Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Neutrophil is known to critically impact the development of renal diseases (e.g., the clear cell renal cell carcinoma (ccRCC)), whereas the heterogene......

Antigen-Specific Tissue-Resident Memory T Cells in the Respiratory System Were Generated following Intranasal Vaccination of Mice with BCG

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Tissue-resident memory T cells (T-RM) are different from effector memory T cells (T-EM) and central memory T cells (T-CM) and contribute to the protec......

miR-100 Suppresses the Proliferation, Invasion, and Migration of Hepatocellular Carcinoma Cells via Targeting CXCR7

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

This study is to elucidate the functions of miR-100 in hepatocellular carcinoma progression and to explore the underlying mechanisms. Expression level......

iNOS Promotes the Development of Osteosarcoma via Wnt/beta-Catenin Pathway

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Inducible nitric oxide synthase (iNOS), accompanied with protumor and antitumor activity, has been studied in multiple cancers. However, the role of i......

Effects of Fatty Acid Oxidation and Its Regulation on Dendritic Cell-Mediated Immune Responses in Allergies: An Immunometabolism Perspective

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Type 1 allergies, involve a complex interaction between dendritic cells and other immune cells, are pathological type 2 inflammatory immune responses ......

Probiotics Alleviated Nonalcoholic Fatty Liver Disease in High-Fat Diet-Fed Rats via Gut Microbiota/FXR/FGF15 Signaling Pathway

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Gut microbiota (GM) dysbiosis and bile acid (BA) metabolism disorder play an important role in the pathogenesis of nonalcoholic fatty liver disease (N......

Propofol Suppresses Microglia Inflammation by Targeting TGM2/NF-kappa B Signaling

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Background. Propofol is a known intravenous hypnotic drug used for induction and maintenance of sedation and general anesthesia. Emerging studies also......

Suppression of DLBCL Progression by the E3 Ligase Trim35 Is Mediated by CLOCK Degradation and NK Cell Infiltration

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

The majority of diffuse large B-cell lymphoma (DLBCL) patients develop relapsed or refractory disease after standard ruxolitinib, cyclophosphamide, do......

LINC00707 Regulates miR-382-5p/VEGFA Pathway to Enhance Cervical Cancer Progression

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Long noncoding RNAs (LncRNAs) are reported to exhibit crucial roles in cancer progression. LINC00707 is recently indicated to be a significant oncogen......

Interplay between Extracellular Matrix and Neutrophils in Diseases

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

The extracellular matrix (ECM) is a highly dynamic and complex network structure, which exists in almost all tissues and is the microenvironment that ......

TNPO1-Mediated Nuclear Import of FUBP1 Contributes to Tumor Immune Evasion by Increasing NRP1 Expression in Cervical Cancer

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Far upstream element binding protein 1 (FUBP1), a DNA-binding protein, participates in diverse tumor-promoting behaviors by regulating the expression ......

Ursolic Acid Regulates Intestinal Microbiota and Inflammatory Cell Infiltration to Prevent Ulcerative Colitis

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Ulcerative colitis (UC) is a chronic and relapsing inflammatory bowel disorder in the colon and rectum leading to low life-quality and high societal c......

Therapeutic Effect of Matrine on Collagen-Induced Arthritis Rats and Its Regulatory Effect on RANKL and OPG Expression

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Objective. To investigate the effect of matrine on rats with collagen-induced arthritis (CIA) and its regulatory effect on receptor activator of nucle......

Therapeutic Mechanism and Effect of Camptothecin on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice

期刊: JOURNAL OF IMMUNOLOGY RESEARCH, 2021; 2021 ()

Camptothecin (CPT) is a cytotoxic quinoline alkaloid isolated from the bark and branches of the Chinese tree Camptotheca acuminata. CPT inhibits topoi......

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