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First-recruited motor units adopt a faster phenotype in amyotrophic lateral sclerosis

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2021; 599 (17)

Key points Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder of motor neurons, carrying a short survival. High-density mo......

Encoding of vestibular and optic flow cues to self-motion in the posterior superior temporal polysensory area

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2021; 599 (16)

Key points Neurons in the posterior superior temporal polysensory area (STPp) showed significant directional selectivity in response to vestibular, op......

Preserved skeletal muscle oxidative capacity in older adults despite decreased cardiorespiratory fitness with ageing

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2021; 599 (14)

Key points Healthy older adults exhibit lower cardiorespiratory fitness (V?O2peak) than young in the absence of any age-related difference in skeletal......

Delayed KCNQ1/KCNE1 assembly on the cell surface helps I-Ks fulfil its function as a repolarization reserve in the heart

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2021; 599 (13)

Key points In adult ventricular myocytes, the slow delayed rectifier (I-Ks) channels are distributed on the surface sarcolemma, not t-tubules. In adul......

Dynamics of longitudinal dentate gyrus axons associated with seizure

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2021; 599 (8)

Key points Axon collaterals of DG granule neurons project towards neighbouring DG granule cell layer Longitudinal axons in the DG-DG circuit possess d......

Contribution of retrotrapezoid nucleus neurons to CO2-amplified cardiorespiratory activity in spontaneously hypertensive rats

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2021; 599 (4)

Key points This study demonstrates that both CO2-induced respiratory and cardiovascular responses are augmented in spontaneously hypertensive rats (SH......

Junctophilin-4 facilitates inflammatory signalling at plasma membrane-endoplasmic reticulum junctions in sensory neurons

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2021; 599 (7)

Key points Rat somatosensory neurons express a junctional protein, junctophilin-4 (JPH4) JPH4 is necessary for the formation of store operated Ca2+ en......

Different coding strategy of sound information between GABAergic and glutamatergic neurons in the auditory midbrain

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2020; 598 (5)

Key points In the central nucleus of the inferior colliculus (ICC), which acts as the hub of the auditory pathways, how the sound is coded by distinct......

Distinct roles of srGAP3-Rac1 in the initiation and maintenance phases of neuropathic pain induced by paclitaxel

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2020; 598 (12)

Key points Spinal cord dorsal horn srGAP3 (slit-robo GTPase activating protein 3) increases in the initiation phase of neuropathic pain and decreases ......

Presynaptic development is controlled by the core active zone proteins CAST/ELKS

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2020; 598 (12)

Key points CAST/ELKS are positive regulators of presynaptic growth and are suppressors of active zone expansion at the developing mouse calyx of Held.......

Multiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L-IRBIT in the mTAL

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2020; 598 (16)

Key points The roles of the Na+/HCO3- cotransporters NBCn1 and NBCn2 as well as their activators IRBIT and L-IRBIT in the regulation of the mTAL trans......

Cardiomyopathy in obesity, insulin resistance and diabetes

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2020; 598 (14)

The prevalence of obesity, insulin resistance and diabetes is increasing rapidly. Most patients with these disorders have hypertriglyceridaemia and in......

Distinct features of calcium handling and beta-adrenergic sensitivity in heart failure with preserved versus reduced ejection fraction

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2020; 598 (22)

Heart failure with reduced or preserved ejection fraction (respectively, HFrEF and HFpEF) is the leading cause of death in developed countries. Althou......

Lower body negative pressure protects brain perfusion in aviation gravitational stress induced by push-pull manoeuvre

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2020; 598 (15)

The acute negative (-Gz) to positive (+Gz) gravity stress during high-performance aircraft push-pull manoeuvres dramatically reduces transient cerebra......

Anodal and cathodal tDCS modulate neural activity and selectively affect GABA and glutamate syntheses in the visual cortex of cats

期刊: JOURNAL OF PHYSIOLOGY-LONDON, 2020; 598 (17)

Key points The present study showed that anodal and cathodal transcranial direct current stimulation (tDCS) can respectively increase and decrease the......

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