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Interleukin-9 deficiency affects lipopolysaccharide-induced macrophage-related oxidative stress and myocardial cell apoptosis via the Nrf2 pathway both in vivo and in vitro

期刊: BIOFACTORS, 2021; 47 (4)

Previous studies showed that interleukin-9 (IL-9) is involved in cardiovascular diseases, including hypertension and cardiac fibrosis. This study aime......

Antioxidant and reducing lipid accumulation effects of rutin in Caenorhabditis elegans

期刊: BIOFACTORS, 2021; 47 (4)

In this study, the effect of rutin on fatty acid metabolism and antioxidant activity were evaluated. We found that the antioxidant capacity of rutin-t......

The HIF-1/SNHG1/miR-199a-3p/TFAM axis explains tumor angiogenesis and metastasis under hypoxic conditions in breast cancer

期刊: BIOFACTORS, 2021; 47 (3)

Activation of hypoxia-inducible factors (HIFs) as a result of intratumoral hypoxia modulates a cascade of molecular pathways thus leading to angiogene......

Bioinformatics and experimental findings reveal the therapeutic actions and targets of pachymic acid against cystitis glandularis

期刊: BIOFACTORS, 2021; 47 (4)

Pachymic acid (PA), a bioactive ingredient isolated from Poria cocos Wolf, is reported with potential benefits of anti-inflammatory, anti-oxidative ac......

Integrated analysis of the prognostic values of RNA-binding proteins in head and neck squamous cell carcinoma

期刊: BIOFACTORS, ; ()

Head and neck squamous cell carcinoma is a malignant tumor of the upper aerodigestive tract. These RNA-binding proteins (RBPs) influence post-transcri......

BCL-6 promotes the methylation of miR-34a by recruiting EZH2 and upregulating CTRP9 to protect ischemic myocardial injury

期刊: BIOFACTORS, ; ()

Acute myocardial infarction (AMI) and the following heart failure are public health problems faced all over the globe. The current study set out to in......

Hsa_circ_0045714 induced by eupatilin has a potential to promote fracture healing

期刊: BIOFACTORS, ; ()

It is thought that maintaining preosteoblast viability is constructive to fracture healing. Here, we explored the effects of eupatilin on preosteoblas......

Epidermal growth factor/epidermal growth factor receptor moves into the osteoblasts' cell nuclei where it is involved to regulate STAT5's signaling

期刊: BIOFACTORS, ; ()

Epidermal growth factor (EGF) has vital biological impacts on the osteoblasts. However, the knowledge on the cellular properties of EGF/EGFR (epiderma......

Novel roles of Tsukushi in signaling pathways and multiple disease processes

期刊: BIOFACTORS, ; ()

Tsukushi (TSK), a newly identified hepatokine, is a member of the small leucine-rich proteoglycans (SLRPs) family. TSK was originally isolated and ide......

FAM84B acts as a tumor promoter in human glioma via affecting the Akt/GSK-3 beta/beta-catenin pathway

期刊: BIOFACTORS, ; ()

Family with sequence similarity 84, member B (FAM84B) has recently emerged as an oncoprotein in multiple types of cancer. However, whether FAM84B modu......

Restoration of NRF2 attenuates myocardial ischemia reperfusion injury through mediating microRNA-29a-3p/CCNT2 axis

期刊: BIOFACTORS, ; ()

Accumulated studies have been implemented for comprehending the mechanism of myocardial ischemia reperfusion injury (MI/RI). Nuclear factor erythroid-......

Human antigen R (HuR) and Cold inducible RNA-binding protein (CIRP) influence intestinal mucosal barrier function in ulcerative colitis by competitive regulation on Claudin1

期刊: BIOFACTORS, ; ()

To investigate the effects of RNA-binding proteins cold-inducible RNA binding protein (CIRP) and human antigen R (HuR) on expression of Claudin1 and m......

The dietary carcinogen PhIP activates p53-dependent DNA damage response in the colon of CYP1A-humanized mice

期刊: BIOFACTORS, ; ()

Species differences in the metabolism of xenobiotics by cytochrome P450 are critical in evaluating the use of experimental animals in studying toxic c......

Berberine ameliorates neuronal AD-like change via activating Pi3k/PGC epsilon pathway

期刊: BIOFACTORS, ; ()

IR (insulin resistance) in diabetic brain gave rise to the generation of toxic factor A beta 42 and axon collapse which were the marker of AD (Alzheim......

Effects of 1,25(OH)(2)D-3 on lipid droplet growth in adipocytes

期刊: BIOFACTORS, 2020; 46 (6)

This study aimed to explore the effects of 1,25(OH)(2)D-3 on lipid droplet (LD) growth in 3T3-L1 adipocytes of hypertrophy model. Cocktail method was ......

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