笔记详情
标题
Metformin regulates the levels of hormones controlling the energy balance
内容
Metformin regulates the levels of hormones controlling the energy balance
Growth hormones including insulin, IGF-1, leptin and adinopectin that regulate energy metabolism were estimated under metformin treatments in plasma and ascites fluid of the mice. Metformin was most efficient in reducing the levels of insulin, IGF-1 and leptin in both the plasma and ascites of the HED group (Figure 4A–4C). Adiponectin was significantly increased in the plasma but not in the ascites by metformin in the HED mice (Figure 4D). Metformin decreased IGF-1 and leptin levels significantly in both the plasma and ascites of the RD group, while insulin was reduced only in the ascites (Figure 4A–4C). Adiponectin was significantly increased in the plasma but not in the ascites by metformin in the RD mice (Figure 4D). CRD mice still had the lowest levels of IGF-1, insulin and leptin and increased adiponectin as observed previously [13]. In general, HED fed mice showed a tumor promoting environment while mice on CRD showed the inverse profile. Metformin reversed most of these tumor promoting effects of diet in HED and RD, similar to the CRD group; however, CRD was the most effective in maintaining the lowest levels of all growth factors and hormones. 点击翻译
Growth hormones including insulin, IGF-1, leptin and adinopectin that regulate energy metabolism were estimated under metformin treatments in plasma and ascites fluid of the mice. Metformin was most efficient in reducing the levels of insulin, IGF-1 and leptin in both the plasma and ascites of the HED group (Figure 4A–4C). Adiponectin was significantly increased in the plasma but not in the ascites by metformin in the HED mice (Figure 4D). Metformin decreased IGF-1 and leptin levels significantly in both the plasma and ascites of the RD group, while insulin was reduced only in the ascites (Figure 4A–4C). Adiponectin was significantly increased in the plasma but not in the ascites by metformin in the RD mice (Figure 4D). CRD mice still had the lowest levels of IGF-1, insulin and leptin and increased adiponectin as observed previously [13]. In general, HED fed mice showed a tumor promoting environment while mice on CRD showed the inverse profile. Metformin reversed most of these tumor promoting effects of diet in HED and RD, similar to the CRD group; however, CRD was the most effective in maintaining the lowest levels of all growth factors and hormones. 点击翻译
来源
Zaid Al-Wahab. Oncotarget. 2015 Mar 12
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