Solubility improvement of epalrestat by layered structure formation via cocrystallization

Putra, OD; Umeda, D; Nugraha, YP; Furuishi, T; Nagase, H; Fukuzawa, K; Uekusa, H; Yonemochi, E

Yonemochi, E (reprint author), Hoshi Univ, Sch Pharm & Pharmaceut Sci, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan.; Uekusa, H (reprint author), Tokyo Inst Technol, Sch Sci, Dept Chem, Meguro Ku, 2-12-1 Ookayama, Tokyo 1528551, Japan.

CRYSTENGCOMM, 2017; 19 (19): 2614

Abstract

Epalrestat, a drug for diabetic neuropathy, was able to form a cocrystal with a pharmaceutically acceptable coformer of caffeine. The cocrystal was ch......

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