Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL-MedSci.cn

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

Degryse, S; Bornschein, S; de Bock, CE; Leroy, E; Vanden Bempt, M; Demeyer, S; Jacobs, K; Geerdens, E; Gielen, O; Soulier, J; Harrison, CJ; Constantinescu, SN; Cools, J

Cools, J (reprint author), VIB Ctr Canc Biol, Herestraat 49 Bus 912, B-3000 Leuven, Belgium.

BLOOD, 2018; 131 (4): 421

Abstract

The Janus kinase 3 (JAK3) tyrosine kinase is mutated in 10% to 16% of T-cell acute lymphoblastic leukemia (T-ALL) cases. JAK3 mutants induce constitut......

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