DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras

Zhang, XY; Luukkonen, LM; Eissler, CL; Crowley, VM; Yamashita, Y; Schafroth, MA; Kikuchi, S; Weinstein, DS; Symons, KT; Nordin, BE; Rodriguez, JL; Wucherpfennig, TG; Bauer, LG; Dix, MM; Stamos, D; Kinsella, TM; Simon, GM; Baltgalvis, KA; Cravatt, BF

Zhang, XY; Cravatt, BF (corresponding author), Scripps Res Inst, Dept Chem, La Jolla, CA 92307 USA.; Zhang, XY; Cravatt, BF (corresponding author), Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92307 USA.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021; 143 (13): 5141

Abstract

Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these ......

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