25-Hydroxycholesterol amplifies microglial IL-1 beta production in an apoE isoform-dependent manner

Wong, MY; Lewis, M; Doherty, JJ; Shi, Y; Cashikar, AG; Amelianchik, A; Tymchuk, S; Sullivan, PM; Qian, MX; Covey, DF; Petsko, GA; Holtzman, DM; Paul, SM; Luo, WJ

Luo, WJ (corresponding author), Weill Cornell Med, Feil Family Brain & Mind Res Inst, Appel Alzheimers Dis Res Inst, New York, NY 10065 USA.; Paul, SM (corresponding author), Sage Therapeut, Cambridge, MA 02142 USA.

JOURNAL OF NEUROINFLAMMATION, 2020; 17 (1):

Abstract

Background: Genome-wide association studies of Alzheimer's disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in A......

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