Multistep regulation of TFEB by MTORC1

Vega-Rubin-de-Celis, S; Pena-Llopis, S; Konda, M; Brugarolas, J

Brugarolas, J (reprint author), Univ Texas Southwestern Med Ctr Dallas, Simmons Comprehens Canc Ctr, Kidney Canc Program, Dallas, TX 75390 USA.; Brugarolas, J (reprint author), Univ Texas Southwestern Med Ctr Dallas, Hematol Oncol Div, Dept Internal Med,

AUTOPHAGY, 2017; 13 (3): 464

Abstract

The master regulator of lysosome biogenesis, TFEB, is regulated by MTORC1 through phosphorylation at S211, and a S211A mutation increases nuclear loca......

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